Summary
Mouse pancreatic islets microdissected free from, or surrounded by, exocrine cells were used to study the effects of secretin and choleeystokinm-pancreozymin on insulin release. Both secretin and cholecystokinin-pancreozymin potentiated glucose-stimulated insulin release regardless of whether exocrine cells were present. The results fail to support the idea that the presence of the exocrine parenchyma is essential for elicitation of insulin release by these gastrointestinal hormones.
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Guidoux-Grassi, L., Felber, J.-P.: Effect of secretin on insulin release by the rat pancreas. Diabetologia4, 391–392 (1968)
Vanotti, A., Hadjikhani, H., Fasel, J., Guidoux, L., Felber, J.-P.: The endocrine function of the intestinal mucosa. Amer. J. Proctol.20, 68–71 (1969)
Hinz, M., Katsilambros, N., Schweitzer, B., Raptis, S., Pfeiffer, E.F.: The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones. I. The effect of pancreozymin, secretin, gastrinpentapeptide and of glucagon upon insulin secretion of isolated islets of rat pancreas. Diabetologia7, 1–5 (1971)
Goberna, R., Fuasgänger, R.D., Raptis, S., Telib, M., Pfeiffer, E.F.: The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones. II. Insulin responses to secretin and pancreozymin in experimentally-induced pancreatic exocrine insufficiency. Diabetologia7, 68–72 (1971)
Raptis, S., Rau, R.M., Schröder, K.E., Hartmann, W., Faulhaber, J.-D., Clodi, P.H., Pfeiffer, E.F.: The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones. III. Insulin responses to secretin and pancreozymin, and to oral and intravenous glucose, in patients suffering from chronic insufficiency of the exocrine pancreas. Diabetologia7, 160–167 (1971)
Hellerström, C.: A method for the microdissection of intact pancreatic islets of mammals. Acta endocr. (Kbh.)45, 122–132 (1964)
Umbreit, W.W., Burris, R.H., Stauffer, J.F.: Manometric Techniques, 4th edn., p. 132. Minneapolis: Burger Publishing Co. 1964
Heding, L.G.: A simplified insulin radioimmunoassay method. In labelled proteins in tracer studies. Eds. Donato, Milhaud and Sirchis, p. 345–351. Brussels: Euratom 1966
Danielsson, Å.: Effects of glucose, insulin and glucagon on amylase secretion from incubated mouse pancreas. Pflügers Arch. ges. Physiol.348, 333–342 (1974)
Danielsson, A.: Effects of nutritional state and of administration of glucose, glibenclamide or diazoxide on the storage of amylase in mouse pancreas. Digestion.10, 150–161 (1974)
Söling, H.D., Unger, K.O.: The role of insulin in the regulation of α-amylase synthesis in the rat pancreas. Europ. J. clin. Invest.2, 199–212 (1972)
Sergeyeva, M.A.: Microscopic changes in the pancreatic gland of the cat produced by sympathetic and parasympathetic stimulation. Anat. Rec.71, 319–336 (1938)
Kramer, M.F., Tan, H.T.: The peri-insular acini of the pancreas of the rat. Z. Zellforsch.86, 163–170 (1968)
Ferner, H.: Die Dissemination der Hodenzwischenzellen und der Langerhansschen Inseln als funktionelles Prinzip für die Samenkanälchen und das exokrine Pankreas. Z. mikr.-anat. Forsch.63, 35–52 (1958)
Lernmark, Å.: Isolated mouse islets as a model for studying insulin release. Acta diabet. lat.8, 649–679 (1971)
Dupré, J., Curtis, J.D., Unger, R.H., Waddell, R.W., Beck, J.C.: Effects of secretin, pancreozymin or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man. J. clin. Invest.48, 745–747 (1969)
Kalk, W.J., Vinik, A.I., Bank, S., Keller, P., Jackson, W.P.U.: Selective loss of beta cell response to glucose in chronic pancreatitis. Horm. Metab. Res.6, 95–98 (1974)
Iversen, J.: Secretion of glucagon from the isolated perfused canine pancreas. J. clin. Invest.50, 2123–2136 (1971)
Moody, A.J., Markussen, J., Sundby, F., Steenstrup, C., Schaich-Fries, A.: The insulin releasing activity of extracts of the porcine intestinal tract. In: The structure and metabolism of the pancreatic islets. Eds. Falkmer, S., Hellman, B., Täljedal, I.-B., pp. 469–476. Oxford: Pergamon Press 1970
Turner, D.S., Shabaan, A., Etheridge, L., Marks, V.: The effect of an intestinal polypeptide fraction on insulin release in the ratin vitro andin vivo. Endocrinology93, 1323–1328 (1973)
Marks, V., Samols, E.: Intestinal factors in the regulation of insulin secretion. Advanc. Metab. Disorders4, 1–38 (1970)
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Danielsson, Å., Lernmark, Å. Effects of pancreozymin and secretin on insulin release and the role of the exocrine pancreas. Diabetologia 10, 407–409 (1974). https://doi.org/10.1007/BF01221629
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DOI: https://doi.org/10.1007/BF01221629