Summary
Hepatic insulin clearance was studied in normal male and female Wistar rats using the isolated liver perfusion technique and the dextran coated charcoal radioimmunoassay for insulin. The following results were obtained: — 1. In male rats there was a progressive increase in clearance with increasing body weight, liver weight and age. — 2. In adult female rats clearance was significantly greater than in comparable males, but no relationship between liver weight and clearance was observed. — 3. With each increase in insulin concentration there was an apparent decrease in clearance.
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McCarroll, A.M., Buchanan, K.D. Physiological factors influencing insulin clearance by the isolated perfused rat liver. Diabetologia 9, 174–177 (1973). https://doi.org/10.1007/BF01219779
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DOI: https://doi.org/10.1007/BF01219779