Summary
The inter-relation between hypertriglyceridaemia and glucose intolerance has been studied experimentally in fifteen male subjects by measuring the effect of acute elevation of plasma triglyceride (injection of Intralipid intravenously) upon oral glucose tolerance. The induced hypertriglyceridaemia did not alter the mean blood glucose or plasma insulin response to oral glucose. The associations between plasma triglyceride levels and glucose tolerance observed both in general population studies and in “patient” populations are probably due to a mutual link with a further factor or factors.
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Abranas, M.B., Jarrett, R.J., Keen, H., Boyns, D.R., Crossley, J.N.: Oral glucose tolerance and related factors in a normal population sample. II. Inter-relationship of glycerides, cholesterol and other factors with the glucose and insulin response. Brit. med. J.1969 I, 599–602
Albrink, M.J., Davidson, P.C.: Impaired glucose tolerance in patients with hypertriglyceridaemia. J. Lab. clin. Med.67, 573–584 (1966)
Bagdade, J.D., Bierman, E.L., Porte, D.: Influence of obesity on the relationship between insulin and triglyceride levels in endogenous hypertriglyceridemia. Diabetes20, 664–672 (1971)
Berchtold, P., Bjorntorp, P., Gustafson, A., Lindholm, B., Tibblin, G., Wilhelmsen, L.: Glucose tolerance, plasma insulin and lipids in relation to adipose tissue cellularity in men after myocardial infarction. Acta. med. scand.191, 35–41 (1972)
Bierman, E.L., Porte, D.: Carbohydrate intolerance and lipemia. Ann. Intern. Med.68, 926–932 (1968)
Boyns, D.R., Crossley, J.N., Abrams, M.E., Jarrett, R.J., Keen, H.: Oral glucose tolerance and related factors in a normal population sample. I. Blood sugar, plasma insulin, glyceride and cholesterol measurements and the effects of age and sex. Brit. med. J.1969 I, 595–598
Brunzell, J.D., Lerner, R.L., Hazzard, W.R., Porte, D., Bierman, E.L.: Improved glucose tolerance with high carbohydrate feeding in mild diabetes. New Engl. J. Med.284, 521–524 (1971)
Carroll, K.F., Nestel, P.J.: Effect of long-chain triglyceride on human insulin secretion. Diabetes21, 923–929 (1972)
Felber, J.F., Vannotti, A.: Effects of fat infusion on glucose tolerance and insulin plasma levels. Med. Exp.10, 153–156 (1964)
Frederickson, D.S., Levy, R.I., Lees, R.S.: Fat transport in lipoproteins — an integrated approach to mechanisms and disorders. New Engl. J. Med.276, 32–44 et seq. (1967)
Glueck, C.J., Levy, R.I., Frederickson, D.S.: Immuno-reactive insulin, glucose tolerance and carbohydrate inducibility in Types II, III, IV and V hyperlipoproteinemia. Diabetes18, 739–747 (1969)
Lewis, B., Böberg, J., Mancini, M., Carlson, L.A.: Determination of the intravenous fat tolerance test with Intralipid by nephelometry. Atherosclerosis15, 83–86 (1972)
Owen, W.C., Kreisberg, R. A., Siegal, A.M.: Carbohydrate-induced hypertriglyceridemia: inhibition by phenformin. Diabetes20, 739–744 (1971)
Nikkilä, E.A., Taskinen, M.R.: Hypertriglyceridemia and insulin secretion, p. 220. In: “Atherosclerosis”, Proceedings of the Second International Symposium, (Ed. Jones, R.J.). New York: Springer-Verlag 1970
Seyffert, W. A., Jr., Madison, L.L.: Physiologic effects of metabolic fuels on carbohydrate metabolism. I. Acute effect of elevation of plasma free fatty acids on hepatic glucose output, peripheral glucose utilisation, serum insulin and plasma glucagon levels. Diabetes16, 765–776 (1967)
Thorell, J., Persson, B., Sterky, E.: Effect of fat infusion on plasma glucose, FFA, glycerol and insulin levels during intravenous and oral glucose tolerance tests (Abstract). Diabetologia2, 232 (1966)
Wilson, W.S., Hulley, S.B., Burrows, M.I.: Serial lipid and lipoprotein responses to the A.H.A. fat-controlled diet. Amer. J. Med.51, 491–503 (1971)
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Gibson, T., Fuller, J.H., Grainger, S.L. et al. Intralipid triglyceride and oral glucose tolerance. Diabetologia 10, 97–100 (1974). https://doi.org/10.1007/BF01219663
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DOI: https://doi.org/10.1007/BF01219663