Summary
GFR estimated by the total clearence of51Cr-EDTA increases from 41 to 60 ml/min·m2 at the onset and during the development of marked hyperglycaemia and obesity in female diabetic mice (db/db) of the C57BL/6J and the C57BL/KsJ strains (blood sugar rises from 160 to 400 mg/100 ml). GFR decreases slowly in older diabetic mice (>120 days old) approaching the control values (42±7 ml/ min·m2) and then decreases still further. The total clearance of14C-hippuric acid is unaltered indb/db mice and controls between 45 and 150 days of age (96±20 ml/min·m2). This suggests no alteration of RPF during the development of the diabetic syndrome. The glomerular hyperfiltration of diabetic mice lasts until they are 120 days old and shows no correlation with the different blood glucose levels typical for diabetic mice (db/db) of the two strains.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Editorial: Glomerular disease in diabetes. Lancet1972 II, 1403–1404
Berns, A.W., Owens, C.T., Hirata, Y., Blumenthal, H.T.: The pathogenesis of diabetic glomerulosclerosis. II. A demonstration of insulin-binding capacity of the various histopathological components of the disease by fluorescence microscopy. Diabetes11, 308–317 (1962)
Bonatz, K.G., Hardt, H., Adam, W.E., Bettge, S.: Probleme der Bestimmung des renalen Plasmastromes mit ortho-J131-Hippursäure. Klin. Wochenschr.45, 814–817 (1967)
Botsch, H., Hahn, W., Scholz, A., Meinhold, H.: Neue Ergebnisse zum Problem der Messung des Nierenplasmastromes mit radioaktiv markiertem Hippuran. Fortschr. Geb. Roentgenstr. Nuklear med.119, 596–600 (1973)
Coleman, D.L., Burkart, D.L.: Plasma corticosterone concentrations in diabetic (db) mice. Diabetologia13, 25–26 (1977)
Coleman, D.L., Hummel, K.P.: Hyperinsulinaemia in preweaning diabetes (db) mice. Diabetologia10, 607–610 (1974)
Coleman, D.L., Hummel, K.P.: Studies with the mutation, diabetes, in the mouse. Diabetologia3, 238–248 (1967)
Desjardins, C.: Pituitary growth hormone and its hypothalamic releasing factor in normal and genetically diabetic mice. Proc. Soc. Exp. Biol. Med.130, 1–4 (1969)
Ditzel, J., Junker, K.: Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics. Br. Med. J. 1972 II, 13–19
Dost, F.H.: Pharmakokinetik. Stuttgart: Georg Thieme-Verlag 1968
Foreland, M., Pullman, T.N., Lavender, A.R., Aho, I.: The renal excretion of ethylenediaminetetraacetate in the dog. J. Pharmacol. Exp. Ther.153, 142–147 (1966)
Hackbarth, H.: Zur Nierenfunktion und Albuminurie kleiner Versuchstiere. Vet. Diss. Hannover (1977)
Herberg, L., Coleman, D.L.: Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism26, 59–99 (1977)
Herberg, L., Kley, H.K.: Adrenal function and the effect of a high-fat diet on C57BL/6J and C57BL/6Job/ob mice. Horm. Metab. Res.7, 410–415 (1975)
Hummel, K.P., Coleman, D.L., Lane, P.W.: The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57/BL6J strains Biochem. Genet.7, 1–13 (1972)
Katz, A.I., Lindheimer, M. D.: Actions of hormones on the kidney, Annu. Rev. Physiol.39, 97–134 (1977)
Katz, A.I., Toback, F.G., Lindheimer, M.D.: Independence of onset of compensatory kidney growth from changes in renal function. Am. J. Physiol.230, 1067–1071 (1976)
Kroustrup, J.P., Gundersen, H.J., Osterby, R.: Glomerular size and structure in diabetes mellitus. III. Early enlargement of the capillary surface. Diabetologia13, 207–210 (1977)
Like, A.A., Lavine, R.L., Poffenbarger, P.L., Chick, W.L.: Studies in the diabetic mutant mouse. Am. J. Pathol.66, 193–203 (1972)
Mogensen, C.E.: Kidney functions and glomerular permeability to macromolecules in juvenile diabetes. Dan. Med. Bull.19, 1–40 (1972)
Mogensen, C.E., Anderson, M.J.F.: Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: Normalization by insulin-treatment. Diabetologia11, 221–224 (1975)
Naeye, R.: Organ abnormalities in a diabetic mouse. Am. J. Pathol.52, 41a-42a (1968)
Osterby, R., Gundersen, H.J.G.: Glomerular size and structure in diabetes mellitus. Diabetologia11, 225–229 (1975)
Pixberg, H.-U.: Bestimmung des Glomerulusfiltrates bei fallendem 51-Cr-EDTA-Plasmaspiegel. Strahlentherapie136, 700–704 (1968)
Schwartz-Porsche, D.-M., Botsch, H., Scholz, A.: Simultane Clearancebestimmungen mit 51-Cr-EDTA, Inulin, 125-J-Hippuran und PAH beim Hund. Zbl. Veterinärmed. Reihe [A]19, 193–213 (1972)
Siperstein, M.D., Unger, R.H., Madison, L.L.: Studies of muscle capillary basement-membranes in normal subjects, diabetic, and prediabetic patients. J. Clin. Invest.47, 1973–1999 (1968)
Spiro, R.G.: Search for a biochemical of diabetic microangiopathy Diabetologia12, 1–14 (1976)
Stacy, B.D., Thorburn, G.D.: Chromium-51 ethylenediaminetetraacetate for estimation of glomerular filtration rate. Science152, 1076–1077 (1966)
Tuman, R.W., Doisy, R.J.: The influence of age on the development of hypertriglyceridaemia and hypercholesterolaemia in genetically diabetic mice. Diabetologia13, 7–11 (1977)
Wyse, B.M., Dulin, W.E.: The influence of age and dietary conditions on diabetes in the db mouse. Diabetologia6, 268–273 (1970)
Weber, E.: Grundriβ der Biologischen Statistik. Jena: VEB Gustav Fischer Verlag 1972
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gärtner, K. Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice (C57BL/6Jdb/db and C57BL/KsJdb/db). Diabetologia 15, 59–63 (1978). https://doi.org/10.1007/BF01219330
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01219330