Summary
The effects of the chronic administration of sulphonylureas on glucagon secretion were studied in two groups of normal volunteers. One group (n = 7) received glipizide, 10 mg daily, in a single dose, for seven days. The other group (n = 6) received glibenclamide under the same conditions. Basal glucagon and insulin levels and the response of these hormones to an arginine stimulus were studied before and after the sulphonylurea course. — After treatment, neither the basal glucagon values nor the arginine-induced glucagon secretion was significantly altered when compared to the control experiments. The insulin curves showed great variability, being increased in some cases and decreased in others. The mean results showed no significant change in the insulin secretion pattern after sulphonylurea administration. — Our data do not lend support to the hypothetical action of sulphonylureas through the alpha cell.
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This work has been in part supported by I.N.P. grant 12-071-72.
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Marco, J., Valverde, I. Unaltered glucagon secretion after seven days of sulphonylurea administration in normal subjects. Diabetologia 9 (Suppl 1), 317–319 (1973). https://doi.org/10.1007/BF01218441
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DOI: https://doi.org/10.1007/BF01218441