Summary
The relationship of insulin secretion to different types of lipid disorders was studied in 54 nonobese coronary patients with hyperlipidemia. Nineteen patients had hypercholesterolemia and normal triglycerides (type II), and 35 had endogenous hypertriglyceridemia with or without elevated cholesterol levels. Carbohydrate abnormalities and increased insulin concentrations were much more frequent in the hypertriglyceridemic group than in the type II group. Treatment designed to lower insulin levels resulted in no significant serum lipid changes in the type II subjects. In those with hypertriglyceridemia, a decrease in insulin accompanied appreciable falls in triglyceride and cholesterol levels. Mild carbohydrate abnormalities with insulin hypersecretion were closely associated with endogenous hypertriglyceridemia, but appeared to play no major role in type II hyperlipidemia.
Résumé
La relation entre la sécrétion d'insuline et différents types de perturbations lipidiques a été étudiée chez 54 patients coronariens non-obèses, présentant une hyperlipidémie. Dix-neuf patients avaient de l'hypercholestérolémie et des taux de triglycérides normaux (type II), et 35 avaient de l'hypertriglycéridémie endogène avec ou sans élévation des taux de cholestérol. Les anomalies des hydrates de carbone et les concentrations élevées d'insuline étaient bien plus fréquentes dans le groupe hypertriglycéridémique que dans le groupe du type II. Un traitement destiné à abaisser les taux d'insuline n'a pas provoqué de modifications significatives des lipides sériques chez les sujets du type II. Chez les sujets ayant une hypertriglycéridémie, une diminution du taux d'insuline accompagnait des diminutions appréciables des taux de triglycérides et de cholestérol. De légères anomalies des hydrates de carbone ainsi qu'une hypersécrétion d'insuline étaient étroitement liées à l'hypertriglycéridémie endogène, mais ne semblaient pas jouer un rôle majeur dans l'hyperlipidémie du type II.
Zusammenfassung
Bei 54 nicht übergewichtigen Koronarpatienten mit Hyperlipidämie wurde die Beziehung der Insulinsekretion zu verschiedenen Arten von Lipidstörungenuntersucht. 19 Patienten hatten eine Hypercholesterinämie und normale Triglyceridspiegel (Typ II), 35 hatten eine endogene Hypertriglycerinämie mit oder ohne erhöhten Cholesterinspiegel. Anomalien des Kohlenhydratstoffwechsels und erhöhte Insulinkonzentrationen wurden viel häufiger in der Gruppe der Hypertriglycerinämien als in der Gruppe des Typ II angetroffen. Eine den Insulinspiegel senkende Behandlung führte nicht zu signifikanten Änderungen der Serumlipide bei den Fällen des Typ II. Bei den Hypertriglycerinämien wurde die Insulinverminderung von einem beträchtlichen Abfall der Triglycerid- und Cholesterinspiegel begleitet. Geringe Anomalien des Kohlenhydratstoffwechsels mit Insulinhypersekretion waren eng mit einer endogenen Hypertriglycerinämie verknüpft, schienen aber keine größere Rolle bei den Hyperlipidämien des Typ II zu spielen.
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Tzagournis, M., Chiles, R., Herrold, J. et al. The role of endogenous insulin in different hyperlipidemic states. Diabetologia 8, 215–220 (1972). https://doi.org/10.1007/BF01212265
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DOI: https://doi.org/10.1007/BF01212265