Summary
Oral and intravenous glucose tolerance tests were carried out in 14 G6PD-deficient adult Greek patients, presenting with favism, and in 14 control subjects. Abnormal responses to either or both tests were obtained in 9 patients or 64.3 per cent, compared with none in the controls. Most of the abnormal results were seen among the older patients; age, however, did not seem to account for them. The possible significance of decreased carbohydrate tolerance in G6PD-deficiency is discussed.
Résumé
Des tests de tolérance au glucose oral et intraveineux ont été effectués chez 14 sujets grecs ayant une déficience en glucose-6-phosphate déshydrogénase et atteints de favisme, ainsi que chez 14 sujets témoins.
Des réponses anormales soit à l'un, soit aux deux tests ont été obtenues chez neuf patients, soit 64.3% en comparaison avec les témoins chez lesquels aucune réponse n'était anormale. La plupart des résultats anormaux étaient observés chez les patients plus âgés; cependant, l'âge ne semblait pas expliquer ces résultats. On discute de la signification possible de la tolérance diminuée aux hydrates de carbone dans la déficience en glucose-6-phosphate déshydrogénase.
Zusammenfassung
Bei 14 erwachsenen griechischen Patienten mit G6PD Mangel und den Symptomen eines Favismus und bei 14 stoffwechselgesunden Vergleichspersonen wurden orale und i.v. Glucosetoleranztests durchgeführt. Bei neun, bzw. 64.3% der Patienten, hingegen bei keiner der Kontrollpersonen fielen einer oder beide Tests pathologisch aus. Der größte Teil der anormalen Ergebnisse fand sich bei den älteren Patienten, doch schien das Lebensalter selbst nicht den entscheidenden Grund darzustellen. Die Frage der Bedeutung einer herabgesetzten Glucosetoleranz bei G6PD-Mangel wird diskutiert.
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Billis, A.G., Xefteris, E.D., Ioannides, P.J. et al. Abnormal glucose tolerance in favism. Diabetologia 6, 425–429 (1970). https://doi.org/10.1007/BF01212076
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DOI: https://doi.org/10.1007/BF01212076