Summary
The response of plasma glucose, insulin, growth hormone and cortisol to administration of small glucose loads by a previously described, primed infusion technique was determined in normal, diabetic and normal subjects who had been treated with pempidine. The normal subjects treated with pempidine had a glucose response similar to that observed in diabetics and an insulin response similar to that in ‘late-onset’ diabetics. Pempidine did not appear to affect growth hormone or cortisol response to glucose, but did inhibit the post-glucose fall in plasma insulin levels. Plasma cortisol levels tended to fall in response to this form of glucose administration. These findings are consistent with the concept of continuously acting, neural modification of glucose homeostasis in normal subjects, and the possibility that some of the early manifestations of diabetes result from a disturbance of this control.
Résumé
Les réponses des taux sanguins du glucose, de l'insuline, de l'hormone de croissance et du cortisol ont été étudiées pendant l'administration de petites quantités de glucose par une technique antérieurement décrite d'infusion précédée d'une injection chez des sujets normaux, des diabétiques et des sujets normaux ayant été traités par la pempidine. Les sujets normaux prétraités par la pempidine présentaient une réponse glucidique comparable à celle des diabétiques et une réponse insulinique semblable à celle des diabétiques âgés. La pempidine ne semblait pas influencer la réponse de l'hormone de croissance et du cortisol aprés glucose, mais empêchait la baisse post-glucidique des taux plasmatiques de l'insuline. Avec cette méthode d'administration du glucose les taux du cortisol avaient tendance à diminuer. Les résultats sont en accord avec la conception d'une modification neurale permanente de l'homéostasie du glucose chez les sujets normaux et avec la possibilité qu'une part des manifestations précoces du diabéte résultent d'un dérangement de ce contrôle.
Zusammenfassung
Das Verhalten von Blutzucker, Insulin, Wachstumshormon und Cortisol im Plasma nach Zufuhr kleiner Glucosemengen mittels einer früher beschriebenen Methode, bei der nach schneller Injektion eine Dauerinfusion von Glucose erfolgt, wurde bei Stoffwechselgesunden, Diabetikern und stoffwechselgesunden Probanden untersucht, die mit Pempidin behandelt worden waren. Die mit Pempidin vorbehandelten Kontrollpersonen zeigten einen Glucose-Anstieg, wie er bei Diabetikern zu beobachten ist, und eine Insulinausschüttung wie Altersdiabetiker. Pempidin schien das Verhalten von Wachstumshormon und Cortisol nach Glucose nicht zu beeinflussen, hemmte aber den Abfall der Plasma-Insulinspiegel nach Glucose-Gabe. -Die Plasma-Cortisolspiegel zeigten bei dieser Art der Glucose-Verabreichung eine fallende Tendenz. Die Befunde stimmen überein mit der Annahme einer dauernd wirksamen nervalen Steuerung der Glucose-Homöostase bei Normalpersonen und mit der Möglichkeit, daß einige der Früherscheinungen des Diabetes auf einer Störung dieser Steuerungsmechanismen beruhen.
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Submitted as part fulfillment of the requirements for Doctor of Medicine, Monash University, Melbourne, 1967.
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Burr, I., Hudson, W., Page, D. et al. Observations on the effect of a ganglion blocking agent on responses to intravenous glucose infusion. Diabetologia 6, 467–472 (1970). https://doi.org/10.1007/BF01211885
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DOI: https://doi.org/10.1007/BF01211885