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A simple colorimetric method for the assay of penicillin G salt and penicillamine by oxidation with iodate

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Abstract

A simple colorimetric procedure is described for determination of penicillin G salt and penicillamine. It is based on oxidation with potassium iodate at room temperature and measurement of the liberated iodine at 520 nm after extraction with carbon tetrachloride. Compared with other procedures, this method proved to be more rapid, highly reproducible and reasonably accurate. The relative standard deviation did not exceed 0.9% and 0.4% for penicillin and penicillamine, respectively. The procedure has been successfully applied to pharmaceutical preparations containing either of the two compounds.

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Authors and Affiliations

  1. Microanalytical Research Laboratory, National Research Centre, Dokki, Cairo, Egypt

    Amir Besada & Nabil B. Tadros

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  1. Amir Besada
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  2. Nabil B. Tadros
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Besada, A., Tadros, N.B. A simple colorimetric method for the assay of penicillin G salt and penicillamine by oxidation with iodate. Mikrochim Acta 92, 225–228 (1987). https://doi.org/10.1007/BF01201843

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  • DOI: https://doi.org/10.1007/BF01201843

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