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Quantitative analysis of phenethylamine derivatives by thin layer chromatography. Determination of psychotropic drugs and ephedra bases

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Summary

The reactions between phenethylamine derivatives and sodiumβ-naphthoquinone-4-sulfonate were investigated. In weakly alkaline condition, amphetamine, methamphetamine, 2,5-dimethoxy-4-methylamphetamine and mescaline, which are the most representative awaking drugs, gave strongly colored reaction products. Under optimum conditions, the recovery was found to be almost complete and ng order detection was easily carried out. The results of TLC of these colored products suggest that this method is useful for the detection of these drugs, especially for screening purpose. Quantitative analysis was also possible. This method was applied to the separate determination ofl-ephedrine andd-ø-ephedrine inEphedra herba.

Zusammenfassung

Die Reaktionen von Natrium-β-naphthochinon-4-sulfonat mit Phenäthylamin-Derivaten wurden untersucht. Bei schwach alkalischer Reaktion geben die bekanntesten Weckamine Amphetamin, Methamphetamin, 2,5-Dimethyl-4-methylamphetamin und Meskalin stark gefärbte Reaktionsprodukte. Unter optimalen Bedingungen ist die Ausbeute fast vollständig, der Nachweis von ng-Mengen ist leicht durchführbar. Die Ergebnisse der Dünnschichtchromatographie dieser gefärbten Produkte erweisen die Nützlichkeit des Verfahrens zum Nachweis dieser Drogen. Auch die quantitative Bestimmung war möglich. Das Verfahren wurde zur Bestimmung vonl-Ephedrin undd-ø-Ephedrin nebeneinander inEphedra herba angewendet.

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Authors and Affiliations

  1. Kobe Women's College of Pharmacy, Kobe, Japan

    Yohei Hashimoto, Keiko Tominaga & Masataka Moriyasu

  2. Kinki District Narcotic Control Office, Kobe, Japan

    Masaru Endo & Shigeko Inuzuka

Authors
  1. Yohei Hashimoto
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  2. Masaru Endo
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  3. Keiko Tominaga
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  4. Shigeko Inuzuka
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  5. Masataka Moriyasu
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Hashimoto, Y., Endo, M., Tominaga, K. et al. Quantitative analysis of phenethylamine derivatives by thin layer chromatography. Determination of psychotropic drugs and ephedra bases. Mikrochim Acta 70, 493–504 (1978). https://doi.org/10.1007/BF01197101

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  • DOI: https://doi.org/10.1007/BF01197101

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