Summary
The polarographic procedure can be used for the quantitative analysis of all the aminoazobenzenes tested in this study as indicated by proportionality between diffusion current and concentration. There is no significant correlation between the half-wave potential and carcinogenic potency for rat liver for three monosubstituted and seven disubstituted derivatives ofp-dimethylaminoazobenzene. These ring-substituted azocarcinogens rank from weak to very strong for carcinogenic potency against rat liver. Also aminoazobenzenes such as the noncarcinogenic 4′-amino-4-dimethylaminoazobenzene and the carcinogenic N′,N′-dimethyl-4′-amino-N-formyl-N-methyl-4-aminoazobenzene and N′,N′-dimethyl-4′-amino-N-acetyl-N-methyl-4-aminobenzene have similar have-wave potentials. On the other hand, the noncarcinogenic 4′-aminoazobenzene, 4′-amino-N-methyl-4-aminoazobenzene and N′-methyl-4′-amino-N-methyl-4-aminoazobenzene have half-wave potentials that are about 100 mv more negative than that of all other aminoazobenzenes discussed in this report.
Zusammenfassung
Die Proportionalität zwischen Konzentration und Stromdurchfluß bietet die Grundlage zur polarographischen Bestimmung aller in dieser Arbeit geprüften Aminoazobenzole. Zwischen dem Halbwellenpotential und der carcinogenen Wirkung gegenüber Rattenleber besteht bei drei monosubstituierten und sieben disubstituierten Derivaten desp-Dimethylaminoazobenzols keine signifikante Korrelation. Diese ringsubstituierten Azocarcinogene zweigen schwache bis sehr starke carcinogene Wirkung gegenüber Rattenleber. Aminoazobenzole wie das nicht-carcinogene 4′-Amino-4-dimethylaminoazobenzol und die carcinogenen Verbindungen N′,N′-Dimethyl-4′-amino-N-formyl-N-methyl-4-aminoazobenzol und N′,N′-Dimethyl-4′-amino-N-acetyl-N-methyl-4-aminoazobenzol haben ähnliche Halbwellenpotentiale. Andrerseits ist das Halbwellenpotential der nicht-carcinogenen Verbindungen 4-Aminoazobenzol, 4′-Amino-N-methyl-4-aminoazobenzol und N′-Methyl-4′-amino-N-methyl-4-aminoazobenzol ungefähr um 100 mV negativer als das aller anderen hier behandelten Aminoazobenzole.
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Carruthers, C. Polarographic determination of some carcinogenic aminoazobenzenes. Mikrochim Acta 70, 463–472 (1978). https://doi.org/10.1007/BF01197098
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DOI: https://doi.org/10.1007/BF01197098