Skip to main content
SpringerLink
Log in

Analysis of drugs by AAS via formation of ion pairs

  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

A new procedure for determining nitrogenated bases by forming ion pairs with Fe(SCN)63− is studied. The method consists of extracting the ion pair formed by a nitrogenated base and the inorganic complex Fe(SCN)63− into an organic phase, and measuring the iron in the organic phase by AAS at 248.3 nm. The optimal experimental conditions for determining amylocaine, avacan, bromhexine, diphenhydramine and papaverine are studied. The organic phase used is 1,2-dichloroethane. The standard deviation of the method varies between 10−1 and 10−2. The interferences produced by various substances are studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. García-Vergas, M. Milla, J. A. Pérez-Bustamente,Analyst 1983,108, 1293.

    Google Scholar 

  2. Y. Yamamoto, T. Kumamaru, Y. Hayashi,Talanta 1967,14, 611.

    Google Scholar 

  3. Y. Yamamoto, T. Kumamaru, Y. Hayashi, M. Otsuchi,Bunseki Kagaku 1969,18, 354.

    Google Scholar 

  4. A. Le Bihan, J. Courtot-Coupez,Bull. Soc. Chim. Fr. 1970, 406.

  5. A. Le Bihan, J. Courtot-Coupez,Analusis 1974,2, 695.

    Google Scholar 

  6. Y. Yamamoto, T. Kumamaru, Y. Hayashi, Y. Otani,Bull. Chem. Soc. Jpn. 1969,42, 1714.

    Google Scholar 

  7. Y. Kidani, K. Nakamura, K. Inagaki, H. Koike,Bunseki Kagaku 1975,24, 742.

    Google Scholar 

  8. Y. Minami, T. Mitsui, Y. Fujirama,Bunseki Kagaku 1981,30, 811.

    Google Scholar 

  9. T. Minamikawa, K. Matsumura,Yakugaku Zasshi 1976,96, 440.

    Google Scholar 

  10. S. Tammilehto,Acta Pharm. Fenn. 1979,88, 25.

    Google Scholar 

  11. F. T. Crisp, J. M. Eckart, N. A. Gibson,Anal. Chim. Acta 1979,104, 93.

    Google Scholar 

  12. C. Nerín, A. Garnica, J. Cacho,Anal. Chem. 1985,57, 34.

    Google Scholar 

  13. C. Nerín, J. Cacho, A. Garnica,Anal. Lett. 1985,18 (B15), 1987.

    Google Scholar 

  14. C. Nerín, A. Garnica, J. Cacho,Anal. Chem. 1986,58, 2617.

    Google Scholar 

Download references

Author information

Author notes

  1. A. Garnica

    Present address: Instituto Tecnológico de Aragón, Zaragoza, Spain

Authors and Affiliations

  1. Dept. Química, Escuela Tecnica Superior Ingenieros Industriales, Universidad de Zaragoza, Zaragoza, Spain

    C. Nerín & A. Garnica

  2. Dept. Química Analítica, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain

    J. Cacho

Authors
  1. C. Nerín
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Garnica
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Cacho
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nerín, C., Garnica, A. & Cacho, J. Analysis of drugs by AAS via formation of ion pairs. Mikrochim Acta 90, 117–126 (1986). https://doi.org/10.1007/BF01196826

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01196826

Key words

Search

Navigation