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Indirect determination of micro amounts of medicinal drugs by atomic-absorption spectrometry-measurement of L-ascorbic acid

Indirekte Bestimmung von Mikromengen Arzneimittel durch Atomabsorptions-Spektrometrie

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Summary

Indirect determination of medicinal drugs by atomic-absorption spectrometry is reported. The principle of the method is (1) metal chelate formation, and (2) solvent extraction, (3) AAS determination of the metal. The paper describes the determination of L-ascorbic acid by the reduction of the Cu2+-neocuproine chelate to the Cu+-neocuproine chelate, which is extracted into chloroform in the presence of nitrate.

Zusammenfassung

Die indirekte Bestimmung von Arzneimitteln durch AAS wurde beschrieben. Das Prinzip der Methode besteht in der Bildung eines Metallchelates, der Extraktion mit einem Lösungsmittel und der AAS-Bestimmung des Metalls. Beschrieben wurde die Bestimmung der Askorbinsäure durch Reduktion des Kupfer(II)-Neocuproin-Chelates zu der entsprechenden Cu(I)-Verbindung, die in Gegenwart von Nitrat mit Chloroform extrahiert wird.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, 467, Nagoya, Japan

    Yoshinori Kidani, Reiko Umemoto & Kenji Inagaki

Authors
  1. Yoshinori Kidani
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  2. Reiko Umemoto
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  3. Kenji Inagaki
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Kidani, Y., Umemoto, R. & Inagaki, K. Indirect determination of micro amounts of medicinal drugs by atomic-absorption spectrometry-measurement of L-ascorbic acid. Mikrochim Acta 76, 329–334 (1981). https://doi.org/10.1007/BF01196749

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  • DOI: https://doi.org/10.1007/BF01196749

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