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Development of a Quantitative Determination Technique for Ascorbic Acid in Medicines

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Pharmaceutical Chemistry Journal Aims and scope

A coordination compound of iron(III) ion with 1,10-phenanthroline, or the oxidized form of ferroin (OFF), which was obtained via the reaction of phenanthroline hydrochloride and iron(III) ammonium sulfate (3:1) in acidic solution and standardized by indirect iodometry, was proposed for use as a titrant for quantitative determination of ascorbic acid (AA) in drugs. The developed method for determining AAwas characterized by satisfactory validation indicators of specificity, linearity (r = 0.990), extended analytical range (50 – 170% AA), accuracy (AA recovery 99.6%), precision (RSD 1.3%), and low relative error of determination (å 2.9%). The procedure for AA analysis using OFF did not depend on the solution pH and ionic strength and enabled titrations in colored and cloudy solutions. The technique was tested on various commercial drugs: 5% AAsolution for injection, Revit drops, AA tablets with glucose, and cinnamon rose hips.

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Authors and Affiliations

  1. Pyatigorsk Medical and Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of the Russian Federation, 11 Kalinina Prosp, Pyatigorsk, Stavropol’skii Krai, 357533, Russia

    N. Sh. Kaisheva

  2. Interregional Administration of Rosalkogolregulirovanie in the North Caucasus Federal District, 3/13 Lenina St., Essentuki, Stavropol’skii Krai, Russian Federation, 357600, Russia

    A. Sh. Kaishev

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  1. N. Sh. Kaisheva
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  2. A. Sh. Kaishev
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Correspondence to N. Sh. Kaisheva.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 9, pp. 56 – 64, September, 2023

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Kaisheva, N.S., Kaishev, A.S. Development of a Quantitative Determination Technique for Ascorbic Acid in Medicines. Pharm Chem J 57, 1511–1519 (2023). https://doi.org/10.1007/s11094-023-03018-5

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  • DOI: https://doi.org/10.1007/s11094-023-03018-5

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