Abstract
It was found in chronic experiments in cats, using the recording of local blood flow and oxygen tension (pO 2) in the anterior and posterior hypothalamus in the sleep-wakefulness cycle, that when the phases of sleep are alternated, the changes in these parameters are in different directions: the level of blood flow and the frequency of fluctuation of the pO2 during paradoxical sleep increase in the posterior hypothalamus, while they decrease in the anterior hypothalamus. On the other hand, the opposite pattern is observed during slow-wave sleep. The multidirectionality of the changes in local blood flow level and in the frequency of fluctuations of pO2 in one and the same sleep phase indicate that they are of local origin and must be governed by functional-metabolic shifts in these structures; the functional state of the posterior hypothalamus during paradoxical sleep is assessed on this basis.
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Literature cited
V. B. Grechin and V. N. Borovikova, Slow Non-electrical Processes in the Evaluation of the Functional State of the Human Brain [in Russian], Nauka, Leningrad (1982).
L. D. Zaguskin and S. L. Zaguskina, “The dependence of oxygen tension fluctuations over the surface of nerve cells on its function,” in: The Polarographic Determination of Oxygen in Biological Objects [in Russian], Nauk. Dumka, Kiev (1974), p. 225.
D. Moruzzi, “The synchronizing influence of the brain stem and the inhibitory mechanisms underlying the appearance of sleep under the influence of sensory stimulations,” in: The Electrophysiological Investigation of Higher Nervous Activity [in Russian], Nauka, Moscow (1962), p. 216.
Yu. E. Moskalenko, Measurement of Brain Blood Flow by the Hydrogen Clearance Method [in Russian], Nauka, Leningrad (1986).
L. S. Nikolaishvili, L. Sh. Gobechiya, and N. P. Mitagvariya, “Investigation of the dynamics of oxygen tension in the dorsal hippocampus and the sensorimotor cortex in the sleep-wakefulness cycle,” Fiziol. Zh. SSSR,69, No. 12, 1543 (1983).
T. N. Oniani, The Integrative Function of the Limbic System [in Russian], Metsniereba, Tbilisi (1980).
R. M. Abrams, J. J. Stelwijk, H. Hammel, et al., “Brain temperature and brain blood flow in unanesthetized rats,” Life Sci.,4, No. 2, 2399 (1965).
M. A. Baker and J. H. Hayward, “Autonomic basis for the rise of brain temperature during paradoxical sleep,” Science,157, No. 3796, 1586 (1967).
R. J. Berger, “Bioenergetic functions of sleep and activity rhythms and their possible relevance to aging,” Fed. Proc.,54, No. 1, 97 (1975).
G. Clark, H. W. Magoun, and S. W. Ranson, “Hypothalamic regulation of body temperature,” J. Neurophysiol.,2, No. 1, 61 (1939).
A. L. Findlay and J. N. Wayward, “Spontaneous activity of single neurones in the hypothalamus of rabbit during sleep and waking,” J. Physiol. (England),201, No. 1, 37 (1969).
E. Garcia-Austt, R. Velluti, and J. Villar, “Changes of brain pO2 during paradoxical sleep,” Physiol. Behavior,3, No. 3, 477 (1968).
J. A. Horne, “Factors relating to energy conservation duirng sleep in mammals,” Physiol. Psychol.,5, No. 4, 403 (1977).
C. D. Hull, N. A. Buchwald, B. Dubrovsky, et al., “Brain temperature and arousal,” Explt. Neurol.,12, No. 3, 338 (1965).
S. Jacobson, “Hypothalamus and autonomous nervous system,” in: An Introduction to the Neurosciences, Eds. B. Curtis, S. Jacobson, and E. Marcus, W. B. Saunders, Toronto (1972), p. 386.
H. Kawamura and C. H. Sawyer, “Elevation of brain temperature during paradoxical sleep,” Science,150, No. 3698, 912 (1965).
V. M. Kovalzon, “Brain temperature variations during natural sleep and arousal in white rats,” Physiol. Behavior,10, No. 4, 667 (1973).
D. W. Lübbers, “The meaning of the tissue oxygen distribution curve and its measurement by means of the Pt-electrodes,” in: Oxygen Pressure Recording in Gases, Fluids, and Tissue, Eds. F. Kreuzer and H. N. Herzog, S. Karger, Basel (1969), p. 112.
R. McCook, C. Peiss, and W. Randall, “Hypothalamic temperature and blood flow,” Proc. Soc. Exp Biol. Med.109, No. 7, 518 (1962).
P. L. Parmeggiani, “Interaction between sleep and thermoregulation,” Waking Sleeping,1, No. 2, 123 (1977).
P. L. Parmeggiani, G. Zamboni, and T. Cianci, “Absence of thermoregulatory vasomotor responses during fast wave sleep in cats,” EEG Clin. Neurophysiol.,42, No. 3, 372 (1977).
D. D. Reneau, R. S. Farland, and J. H. Halsey, “Metabolism prediction based on measurement of pO2 and flow of the same locus during seizures and barbiturate suppression of EEG,” in: Oxygen Transport to Tissue, Eds. I. Silver, M. Ericinska, and H. Bicher, Plenum Press, London (1977), p. 213.
L. Sokoloff, “Relationship among local functional activity, energy metabolism and blood flow in the central nervous system,” Fed. Proc.,40, No. 8, 8311 (1981).
K. Stossek, D. W. Lübbers, and N. Cotton, “Determination of local blood flow by electrochemically generated hydrogen. Construction and application of the measuring probe,” Pflügers Arch. ges. Physiol.,348, No. 4, 225 (1974).
S. Tachibana, “Local temperature, blood flow, and electrical activity correlations in the posterior hypothalamus of the cat,” Exp. Neurol.,16, No. 2, 148 (1966).
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 39, No. 3, pp. 536–542, May–June, 1989.
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Nikolaishvili, L.S., Gobechiya, L.S. & Devdariani, M.I. Blood-flow and pO2 in the posterior hypothalamus of cats during paradoxical sleep. Neurosci Behav Physiol 20, 262–267 (1990). https://doi.org/10.1007/BF01195465
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DOI: https://doi.org/10.1007/BF01195465