Summary
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1.
Methods have been developed for the preparation of three stereoisomers of 2,5-dimethyl-4-piperidinol (II), and numerous derivatives of these have been described.
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2.
By the methylation of the isomeric piperidinols (II), three stereo isomeric 1,2,5-trimethyl-4-piperidinols (VII) have been prepared, and a number of their derivatives have been described. All of the stereoisomeric benzoic esters that we have prepared (IV and VIII) have been tested for their activity as local anesthetics.
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Literature cited
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Nazarov, I.N., Sokolov, D.V. & Rakcheeva, V.N. Heterocyclic compounds Communication XXIX. Stereoisomerism of 2,5-dimethyl-4-piperidinoil, 1,2,5-trimethyl-4-piperidinol, and their derivatives. Russ Chem Bull 3, 65–76 (1954). https://doi.org/10.1007/BF01195426
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DOI: https://doi.org/10.1007/BF01195426