Skip to main content
SpringerLink
Log in

Influence of small cardioactive peptide (b) on the efficiency of synaptic transmission and the excitability of command neurons of the defensive behavior of the edible snail

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

The application of a small cardioactive peptide (SCPb) (mCPb) in a concentration of 5 ·10−8 mole/l to a physiological solution washing the isolated central nervous system of the edible snail leads to an increase in the amplitude of the summated EPSP evoked by rhythmic stimulation of the intestinal nerve in the command neurons of defensive behavior by 55±20%. In addition to the change in the magnitude of the synoptic input, SCPb induces an increase in the excitability of the same neurons by 92±57%, tested intracellularly. These influences may lead to a total decrease in the threshold of the reaction of the neuronal network of the defensive behavior in response to stimulation. The possibility of the integration of integral behavior with the aid of peptides which are effective in very small concentrations is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. I. V. Kudryashova and D. B. Logunov, “The dynamics of the change in the excitability of neurons during the action of an analog of vasopressin in the edible snail,”Zhurn. Vyssh. Nervn. Deyat.,36, No. 6, 1116–1124 (1986).

    Google Scholar 

  2. D. B. Logunov and P. M. Balaban, “The monosynaptic connection between identified neurons of the edible snail,”Doklady Akad. Nauk SSSR,240, No. 1, 237–240 (1978).

    Google Scholar 

  3. O. A. Maksimova and P. M. Balaban,The Neuronal Mechanisms of Plasticity [in Russian], Nauka, Moscow (1983).

    Google Scholar 

  4. M. V. Chistyakova and P. M. Balaban, “The influence of serotonin on the activity of neurons included in the accomplishment of the defensive reflex of the snail,”Zhurn. Vyssh. Nervn. Deyat.,38, No. 6, 1060–1067 (1988).

    Google Scholar 

  5. A. V. Shevelkin, “The activation of the defensive behavior of edible snails during alimentary sensory satiation,”Zhurn. Vyssh. Nervn. Deyat.,39, No. 2, 379–381 (1989).

    Google Scholar 

  6. T. W. Abrams, V. F. Castellucci, J. S. Camarado, et al., “Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex inAplysia by presynaptic facilitation involving cAMP dependent closure of a serotonin-sensitive potassium channel,”Proc. Nat. Acad. Sci. (USA),81, No. 1, 7956–7960 (1984).

    Google Scholar 

  7. P. M. Balaban, I. S. Zakharov, and M. V. Chistyakova, “Role of serotoninergic cells in aversive learning inHelix,” in:Neurobiology of Invertebrates. Transmitters, Modulators and Receptors, J. Salanki and K. S. Rosza (eds.), Akad. Kiadó, Budapest (1988), pp. 519–531.

    Google Scholar 

  8. J. C. Callaway, B. Masinovsky, and K. Graubad, “Co-localisation of SCP-like and FMRF-amide-like immunoreactivities in crustacean nervous systems,”Brain Res.,405, No. 2, 295–304 (1985).

    Google Scholar 

  9. E. R. Kandel, S. Schacher, V. F. Castellucci, and P. Goelet, “The long and short of memory inAplysia: a molecular perspective,” in:Fidia Research Foundation Neuroscience Award Lectures, Liviana Press, Padua (1986), pp. 7–51.

    Google Scholar 

  10. P. E. Lloyd, “Distribution of molecular characteristics of cardioactive peptides in the snailHelix aspersa,”J. Compar. Physiol.,128, No. 3, 269–276 (1978).

    Google Scholar 

  11. P. E. Lloyd, “Cardioactive neuropeptides in gastropods,”Federat. Proc.,41, No. 13, 2948–2952 (1982).

    Google Scholar 

  12. P. E. Lloyd, “The small cardioactive peptides: A class of modulatory neuropeptides inAplysia,”Trends Neurosci.,9, No. 9, 428–432 (1986).

    Google Scholar 

  13. P. E. Lloyd, I. Kupfermann, and K. R. Weiss, “Evidence for parallel actions of a molluscan neuropeptide and serotonin in mediating arousal inAplysia,”Proc. Nat. Acad. Sci. (USA),81, No. 9, 2934–2937 (1984).

    Google Scholar 

  14. P. E. Lloyd, I. Kupfermann, and K. R. Weiss, “Two endogenous neuropeptides (SCPa and SCPb) produce a cAMP-mediated stimulation of cardiac activity inAplysia,”J. Compar. Physiol.,156A, No. 6, 659–667 (1985).

    Google Scholar 

  15. H. R. Morris, M. Panico, A. Karplus, et al., “Elucidation by FAB-MS of the structure of a new cardioactive peptide fromAplysia,”Nature,300, No. 5979, 643–645 (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow

    N. I. Bravarenko

Authors
  1. N. I. Bravarenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 41, No. 1, pp. 107–112, January–February, 1991.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bravarenko, N.I. Influence of small cardioactive peptide (b) on the efficiency of synaptic transmission and the excitability of command neurons of the defensive behavior of the edible snail. Neurosci Behav Physiol 22, 148–152 (1992). https://doi.org/10.1007/BF01192389

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01192389

Keywords

Search

Navigation