Abstract
The application of 10−5–10–6 M dopamine to physiologic saline surrounding snail CNS leads to decreased excitability of the LPa7 neuron (presynaptic in relation to the defensive behavior command neurons) and decreased amplitude of the monosynaptic excitatory postsynaptic potential (EPSP) in the command neurons brought about by intracellular stimulation of the LPa7 neuron. In addition, dopamine causes an average 70% decrease in the amplitude of the summation EPSP in command neurons in response to intestinal nerve stimulation, a 6–8 mV change in the resting potential towards hyperpolarization, and an average 20% decrease in the command neurons' input resistance. These actions can lead to an overall increase in the threshold of the defensive system's reaction to stimulation. The effect of dopamine on command neurons is significantly reduced in the presence of serotonin. In the presence of dopamine, the efficacy of serotonin action on the size of the response elicited in command neurons is reduced. Based on the data obtained, it was concluded that the interrelation of dopamine and serotonin concentrations could be the basis for the formation of behavioral choice in snails.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
P. M. Balaban, I. S. Zakharov, O. A. Maksimova, and M. B. Chistyakova, “Role of serotonin in formation of the defensive reflex to food in snails,” Neirofiziologia,18, No. 3, 291–298 (1986).
G. N. Galanina, I. S. Zakharov, O. A. Maksimova, and P. M. Balaban, “Role of the gigantic serotonin-containing cell of the snail cerebral ganglion in the organization of food-acquiring behavior,” Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova,36, No. 1, 110–115 (1986).
D. A. Sakharov, Genealogy of Neurons [in Russian], Nauka, Moscow (1974).
D. A. Sakharov, Synaptic and Nonsynaptic Models of the Neuronal System [in Russian], Nauka, Kazan' (1985), pp. 78–80.
E. I. Solntseva and O. V. Borisova, “Atypical responses to dopamine in snail neurons,” Byull. Éksp. Biol. Med.,95, No. 4, 3–6 (1983).
P. Ascher, “Inhibitory and excitatory effects of dopamine onAplvsia neurons,” J. Physiol.,225, No. 2, 173–209 (1972).
P. M. Balaban, I. S. Zakharov, and M. V. Chistyakova, “Localization of plastic changes evoked by aversive learning in the nervous system of the snailHelix lucorum L.,” Neuroscience,22, (1987).
V. W. Pentreath, M. S. Berry, and N. N. Osborne, “The serotonergic cerebral cells in Gastropods,” in: Biology of Serotonergic Transmission, N. N. Osborne (ed.), Wiley, New York (1982), pp. 457–513.
D. A. Sakharov and J. Salanky, “Dopaminergic transmission of mechanosensory input to theHelix brain. An electrophysiological study of snails treated with 6-hydroxydopamine” in: Neurotransmitters. Comparative Aspects, J. Salanky and T. M. Turpaev (eds.), Akadémial Kiadó, Budapest (1980), pp. 359–384.
R. G. Walker et al., “The pharmacology ofHelix dopamine receptors of specific neurons in the snailHelix aspersa,” J. Comp. Biochem. Physiol.,24, 455–469 (1968).
Author information
Authors and Affiliations
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 39, No. 5, pp. 941–948, September–October, 1989.
Rights and permissions
About this article
Cite this article
Chistyakova, M.V. Role of dopamine and serotonin in modulation of snail defensive behavior. Neurosci Behav Physiol 20, 446–452 (1990). https://doi.org/10.1007/BF01192349
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01192349