Summary
The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/μg DNA as compared to 2.1 (0.1) fmol/μg in controls (p<0.05), and it was independent of age and smoking habits. These findings support the hypothesis that carcinogen-DNA adduct formation may be one factor of a constitutionally enhanced lung cancer risk.
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This work was supported by a grant from the German Minister for Research and Technology, BMFT
Definition: Pack-year, 1 packet of cigarettes/day x no. years they were smoked
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Nowak, D., Meyer, A., Schmidt-Preuss, U. et al. Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer. J Cancer Res Clin Oncol 118, 67–71 (1992). https://doi.org/10.1007/BF01192314
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DOI: https://doi.org/10.1007/BF01192314