Skip to main content
SpringerLink
Log in

A mathematical model for plasmid replication and distribution in microbial populations

  • Published:
Biotechnology Letters Aims and scope Submit manuscript

Abstract

A mathematical model and a computer program for its implementation have been developed to predict the distribution of plasmid copy numbers in the individual cells of a microbial population. The kinetics of accumulation of plasmid-free cells. the copy number distribution within the population and the mean copy number can all be calculated using the computer program. The model has been shown to accurately predict these parameters for recombinant plasmids in yeast populations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cooper, N.S., Brown, M.E. and Caulcott, C.A. (1987). Journal of General Microbiology 133, 1871–1880.

    Google Scholar 

  • Cullum, J. and Broda, P. (1979). Genet. Res. Camb. 33, 61–79.

    Google Scholar 

  • Hardy, K.G. (1981). Bacterial Plasmids. Van Nostrand Rheinhold, London.

    Google Scholar 

  • Old, R.W. and Primrose, S.B. (1985). Principles of Gene Manipulation: An introduction to genetic engineering. Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Zakian, V.A., Brewer, B.J. and Fangman, W.L. (1979). Cell 17, 923–934.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, P. O. Box. 88, M60 1QD, Manchester, UK

    W. Greenhalf, D. C. J. Gardner & S. G. Oliver

Authors
  1. W. Greenhalf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. C. J. Gardner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. G. Oliver
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Greenhalf, W., Gardner, D.C.J. & Oliver, S.G. A mathematical model for plasmid replication and distribution in microbial populations. Biotechnol Lett 11, 93–98 (1989). https://doi.org/10.1007/BF01192181

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01192181

Keywords

Search

Navigation