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Synchronizing role of serotonin in regulation of pituitary gonadotropic function in female rats

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Conclusion

  1. 1.

    Injection of serotonin into the mediobasal hypothalamus inhibits LH secretion in phase P. An analogous effect with serotonin injection into the PO region is seen only in the initial period of this stage.

  2. 2.

    Injection of serotonin into the PO region of OE rats does not alter blood concentration of LH, while injection into the mediobasal region results in a decrease in blood LH. Pretreatment of the OE animals with estradiol leads to a recovery of the inhibitory effects of serotonin injected into the rostral hypothalamus and blocks its effects on the release of LH when it is injected into the mediobasal hypothalamus.

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Authors and Affiliations

  1. Laboratory of Endocrine System Physiology, Institute of Experimental Endocrinology and Hormone Chemistry, Academy of Medical Sciences of the USSR, Moscow

    V. N. Babichev & E. I. Adamskaya

Authors
  1. V. N. Babichev
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  2. E. I. Adamskaya
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Translated from Problemy Éndokrinologii, Vol. 28, No. 3, pp. 45–50, May–June, 1982.

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Babichev, V.N., Adamskaya, E.I. Synchronizing role of serotonin in regulation of pituitary gonadotropic function in female rats. Neurosci Behav Physiol 13, 130–134 (1983). https://doi.org/10.1007/BF01190797

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  • DOI: https://doi.org/10.1007/BF01190797

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