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The heightened sensitivity of hypophyseal cells of neonatal rats to corticosteroids

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Conclusions

  1. 1.

    Judging by the intensity of the synthesis of DNA, the total population of hypophyseal cells of rats of the neonatal and nursing periods is more sensitive to the inhibitory influence of corticosteroids than cells of the hypophyses of animals of the prepubertal period and adults.

  2. 2.

    The hypophyseal cells of rats of the early postnatal period react to corticosteroids with attenuation of the synthesis of intracellular proteins, while cells of animals of the prepubertal period and adults do not manifest this reaction.

  3. 3.

    The marked inhibitory effect of the corticosteroids on hypophyseal cells of rats of the neonatal period is specific, since estradiol and testosterone do not alter the synthesis of DNA and total proteins, while progesterone exerts an insignificant inhibitory influence which is much weaker than the effects of corticosteroid.

  4. 4.

    The inhibitory influence of dexamethasone on the synthesis of DNA in the hypophyseal cells of rats of the neonatal period is detected only with prolonged (1–3-day) incubation, whereas inhibitory influence of this glucocorticoid on the synthesis of total proteins is found after as little as 2 h of incubation and is maintained during chronic (3-day) exposure.

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Authors and Affiliations

  1. Laboratory of the Biological Investigations of Hormonal Compounds, All-Union Endocrinological Scientific Center, Institute of Experimental Endocrinology, USSR Academy of Medical Sciences, Moscow

    V. I. Gudoshnikov & V. P. Fedotov

Authors
  1. V. I. Gudoshnikov
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  2. V. P. Fedotov
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Translated from Problemy Éndokrinologii, Vol. 38, No. 1, pp. 61–64, January–February, 1992.

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Gudoshnikov, V.I., Fedotov, V.P. The heightened sensitivity of hypophyseal cells of neonatal rats to corticosteroids. Neurosci Behav Physiol 23, 107–111 (1993). https://doi.org/10.1007/BF01189104

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  • DOI: https://doi.org/10.1007/BF01189104

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