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Incorporation of labeled sex hormones into the ependyma of the mediobasal hypothalamus after intraperitoneal and intraventricular injection into rats

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Conclusions

  1. 1.

    Intraperitoneally injected3H-estradiol is taken up by the ependymal cells of the third ventricle; β1-tanycytes demonstrate the highest level of incorporation of the label.

  2. 2.

    When injected intraventricularly,3H-estradiol and3H-testosterone are taken up by the ependymal cells of the third ventricle; in this case the lowest level of incorporation of the label is found in β1-tanycytes.

  3. 3.

    Comparison of the results relating to incorporation of labeled sex hormones, injected intraperitoneally and intraventricularly, by ependymal cells of the third ventricle suggests that β1-tanycytes can transport sex hormones mainly from the pericapillary space of the median eminence of the hypothalamus into the CSF.

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Authors and Affiliations

  1. Laboratory of Experimental Morphology, Institute of Experimental Endocrinology and Hormone Chemistry, Academy of Medical Sciences of the USSR, Moscow

    I. F. Egorova

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  1. I. F. Egorova
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Translated from Problemy Éndokrinologii, Vol. 30, No. 1, pp. 42–47, January–February, 1984.

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Egorova, I.F. Incorporation of labeled sex hormones into the ependyma of the mediobasal hypothalamus after intraperitoneal and intraventricular injection into rats. Neurosci Behav Physiol 16, 152–156 (1986). https://doi.org/10.1007/BF01186515

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  • DOI: https://doi.org/10.1007/BF01186515

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