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Effect of L-dopa on pituitary gonadotropic function

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Conclusions

  1. 1.

    Administration of L-dopa in a dose of 20 mg/kg for 12 days leads to the premature onset of puberty in sexually immature female rats.

  2. 2.

    Administration of L-dopa in a dose of 100 mg/kg daily for 12 days inhibits the onset of puberty in sexually immature female rats.

  3. 3.

    Administration of L-dopa in a dose of 20 mg/kg daily for 3–4 weeks inhibits ovulation and causes an increase in the LH content in the pituitary of young sexually mature female rats.

  4. 4.

    L-dopa, when injected into rats with an irregular anovulatory cycle in a dose of 20 mg/kg (daily for 2 weeks) causes ovulation, alters the ratio between the phases of estrus and diestrus, and also changes the FSH and LH levels in the pituitary in 50% of cases.

  5. 5.

    Injection of L-dopa in a dose of 20 mg/kg into rats with spontaneous estrus restores their normal sex cycle and ovulation.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad

    É. P. Bekhtereva

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  1. É. P. Bekhtereva
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Translated from Problemy Éndokrinologii, Vol. 22, No. 5, pp. 50–54, July–August, 1976.

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Bekhtereva, É.P. Effect of L-dopa on pituitary gonadotropic function. Neurosci Behav Physiol 7, 211–214 (1976). https://doi.org/10.1007/BF01186055

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  • DOI: https://doi.org/10.1007/BF01186055

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