Conclusions
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1.
We studied the effect of serotonin on the plastic properties of electroexcitable membrane of two types of neurons: habituating and nonhabituating to rhythmic intracellular stimulation with impulses of depolarizing current.
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2.
We demonstrated that serotonin has a facilitating effect on habituating cells (strengthening of responses to stimulation in the presence of depolarization and increase in Ren) and completely blocks their ability to become habituated to rhythmic stimulation. Our data are evidence that the basis for this effect of serotonin may be its inhibition of Cadependent K-conductance.
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3.
Serotonin inhibits responses to stimulation of nonhabituating cells and promotes the development of their habituation to rhythmic stimulation. The basis of this effect is the inhibition by serotonin of Ca-conductance and the resulting switching off of the AP generating mechanism.
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 35, No. 3, pp. 753–759, July–August, 1985.
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D'yakonova, T.L. Regulation of plastic properties of electroexcitable neuron membrane by serotonin. Neurosci Behav Physiol 16, 389–394 (1986). https://doi.org/10.1007/BF01185369
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DOI: https://doi.org/10.1007/BF01185369