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Action of acetylcholine on hippocampal responses during prolonged potentiation and depression following tetanization of the medial septum and dentate fascia

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Conclusions

  1. 1.

    In various experiments both a decline and a rise in the effectiveness of ACh action was demonstrated after tetanization independently of the appearance of a PP or PTD. The “relative” effectiveness of ACh action in most cases declined during the PP and rose during the PTD.

  2. 2.

    The observed changes in the effectiveness of ACh action were nonspecific, since they arose in response to a stimulation not only of the medial septum (cholinergic input) but also the dentate fascia (noncholinergic input). Testing of the responses arising during stimulation of the control (nontetanizing) input for the most part demonstrated a depression in the responses and a decline in the effectiveness of ACh action.

  3. 3.

    No support was found in the present experiments for the hypothesis that the PP and PTD are based on corresponding changes in the sensitivity of the subsynaptic membrane to transmitter. The most probable PP mechanism is an increase in synaptic effectiveness due to an increase in transmitter release. The PTD mechanisms, possibly, involve changes at the level of the postsynaptic membrane and require further analysis.

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Authors and Affiliations

  1. Laboratory of the Electrophysiology of the Conditioned Reflex, Institute of Higher Nervous Activity and Neurophyslology, Academy of Sciences of the USSR, USSR

    R. G. Kozhedub, L. L. Voronin & S. N. Kozhechkin

  2. Laboratory of Functional Synaptology, Brain Institute, Academy of Medical Sciences of the USSR, USSR

    R. G. Kozhedub, L. L. Voronin & S. N. Kozhechkin

  3. Laboratory of Nervous-System Pharmacology, Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow

    R. G. Kozhedub, L. L. Voronin & S. N. Kozhechkin

Authors
  1. R. G. Kozhedub
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  2. L. L. Voronin
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  3. S. N. Kozhechkin
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 32, No. 5, pp. 947–953, September–October, 1982.

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Kozhedub, R.G., Voronin, L.L. & Kozhechkin, S.N. Action of acetylcholine on hippocampal responses during prolonged potentiation and depression following tetanization of the medial septum and dentate fascia. Neurosci Behav Physiol 14, 153–158 (1984). https://doi.org/10.1007/BF01185223

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  • DOI: https://doi.org/10.1007/BF01185223

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