Abstract
Data are presented in this paper regarding the influence of the opioid peptide, dermorphin, and its conjugate on the conditioned reflex activity of sousliks. The administration of dermorphin (0.1 μ/g, subcutaneously) is accompanied by a fall in body temperature, slowing of the baseline vegetative indices, and the sinking of the animal into a sleep-like state. A substantial disturbance of conditioned reflex activity was identified in the late period (delayed effects). Immunization of the hibernating sousliks with a conjugate of dermorphin leads to a gradual awakening of the animals from hibernation, to the normalization of conditioned reflex activity, and to the appearance of the motoric component of a conditioned defense reaction. The question of a possible specific role of dermorphin in the mechanisms of hibernation is discussed.
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Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 78, No. 4, pp. 1–13, April, 1992.
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Sollertinskaya, T.N., Nuritdinov, É.N. & Obukhova, M.F. The role of dermorphin in the regulation of the processes of Hibernation in mammals. Neurosci Behav Physiol 23, 459–469 (1993). https://doi.org/10.1007/BF01183008
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DOI: https://doi.org/10.1007/BF01183008