Skip to main content
SpringerLink
Log in

Participation of cholinergic mechanisms in the origination of the dendritic potential of the cerebral cortex

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

The influence of a series of muscarinic (M) and nicotinic (N) substances on the dendritic potentials of the cerebral cortex was studied in acute experiments on adult cats under deep nembutal anesthesia. M-Antagonists in large doses and M-agonists, N-agonists and acetylcholine elicited a decrease in the amplitude of dendritic potentials. M-Antagonists in small doses and N-antagonists elicited an increase in the amplitude of the dendritic potentials. The application of an anticholinesterase substance, proserine, to the cortex elicited an increase in the amplitude and duration of the dendritic potentials. It is hypothesized that there are postsynaptic M-cholinoreceptors of the M1 type, presynaptic M-cholinoreceptors of the M2 type, and presynaptic N-cholinoreceptors in the neuropil of layer I of the cortex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. G. V. Abuladze, M. A. Gilinskii, and R. Yu. Il'yuchenok, “The role of cholinergic mechanisms in the genesis of some cortical responses,”Neirofiziologiya,2, No. 4, 406–411 (1970).

    Google Scholar 

  2. N. N. Bogolepov, “Some questions of the reciprocal disposition of the processes of nerve and glial cells in the region of synapses,” in:Prolonged Electrical Potentials of the Nervous System [in Russian], Metsniereba, Tbilisi (1969), pp. 113–123.

    Google Scholar 

  3. L. Burchinskaya, V. D. Taranenko, and L. I. Semik, “Intrinsic cholinergic components in the cholinergic innervation of the auditory cortex of the cat brain (zone A1),”Neirofiziologiya,16, No. 1, 81–87 (1984).

    Google Scholar 

  4. V. M. Okudzhava,The Activity of Apical Dendrites in the Cerebral Cortex [in Russian], Izd-vo AN SSSR, Moscow (1963).

    Google Scholar 

  5. L. Z. Pevzner, “The biochemical features of glial cells as the basis for the particpation of the neuroglia in the specific activity of neurons,” in:The Functions of the Neuroglia [in Russian], Metsniereba, Tbilisi (1979), pp. 251–265.

    Google Scholar 

  6. A. I. Roitbak, “Negative components of the direct response of the cortex,”Neirofiziologiya,2, No. 4, 339–348 (1970).

    Google Scholar 

  7. A. I. Sklyarov and A. F. Danilov, “The action of proserine and eserine on synaptic potentials of the sartorius muscle of the frog,”Fiziol. Zh. AN SSSR,63, No. 6, 838–844 (1974).

    Google Scholar 

  8. J. Eccles,The Physiology of the Synapses [Russsian translation], Mir, Moscow (1966).

    Google Scholar 

  9. C. J. Armett and J. M. Ritchie, “The action of acetylcholine and some related substances on condition in mammalian nonmyelinated fibers,”J. Physiol.,155, No. 2, 372–384 (1966).

    Google Scholar 

  10. D. A. Brown, R. J. Docherty, and J. V. Halliwell, “The action of cholinomimetic substances on impulse of the habenulointerpeduncular pathway of the rat in vivo,”J. Physiol.,353, No. 1, 101–109 (1984).

    Google Scholar 

  11. J. D. Dudar and J. C. Szerb, “The effect of topically applied atropine on resting and evoked cortical acetylcholine release,”J. Physiol.,203, No. 3, 741–762 (1969).

    Google Scholar 

  12. F. T. Grews, E. M. Meyer, R. A. Gonzales, et al., “Presynaptic and postsynaptic approaches to enhancing central cholinergic neurotransmission,” in:Treat. Dev. Strateg. Alzheimer's Disease, Madison (1986), pp. 345–419.

  13. C. R. Houser, G. D. Crawford, P. M. Salvaterra, and J. E. Vaughn, “Immunocytochemical localization of choline acetyltransferase inrat cerebral cortex:a study of cholinergic neurons and synapses,”J. Comp. Neurol.,234, No. 1, 17–34 (1985).

    Google Scholar 

  14. S. A. Lipton, “Spontaneous release of acetylcholine effects the physiological nicotine responses of rat retinal ganglion cells in culture,”J. Neurosci.,8, No. 10, 3867–3868 (198).

    Google Scholar 

  15. M.-M. Mesulam and C. Geula, “Nucleus basalis (Ch4) and cortical cholinergic innervation in human brain: observation based on the distribution of acetylcholinesterase and choline acetyltransferase,”J. Comp. Neurol.,275, No. 2, 216–240 (1988).

    Google Scholar 

  16. S. Shimohama, T. Taniguchi, M. Fujiwara, and M. Kameyama, “Biochemical characterization of nicotinic receptors in human brain: binding of (−)-[3H] nicotine,”J. Neurochem.,45, No. 2, 288–293 (1986).

    Google Scholar 

  17. D. G. Spenser, E. Horvath, Jr., and J. Traber, “Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in rat brain: relation to cholinergic nuclei and projections,”Brain Res.,380, No. 1, 59–68 (1986).

    Google Scholar 

  18. M. H. Weiler, V. Misgeld, and D. K. Cheong, “Presynaptic muscarinic modulation of nicotitic excitation in the neostriatum,”Brain Res.,296, No. 1, 111–120 (1984).

    Google Scholar 

  19. H. I. Yamamura, T. W. Vickroy, D. R. Gehlert, et al., “Autoradiographic localization of muscarinic binding sites in the rat central nervous system with (+)-cis[3H]methyldioxolane,”Brain Res.,325, No. 2, 340–344 (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of the General Physiology of the Cerebral Cortex, I. S. Beritashvili Institute of Physiology, Academy of Sciences of the GSSR [AN GSSR], Tbilisi

    G. I. Gedevanishvili

Authors
  1. G. I. Gedevanishvili
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 76, No. 2, pp. 145–151, February, 1990.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gedevanishvili, G.I. Participation of cholinergic mechanisms in the origination of the dendritic potential of the cerebral cortex. Neurosci Behav Physiol 21, 130–135 (1991). https://doi.org/10.1007/BF01182888

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01182888

Keywords

Search

Navigation