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Presynaptic nicotinic cholinoreceptors modulate velocity of the action potential propagation along the motor nerve endings at a high-frequency synaptic activity

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Abstract

Experiments on frog neuromuscular junctions have demonstrated that asynchrony of the acetylcholine quantal release forming the multi-quantal evoked response at high-frequency synaptic activity is caused, in particular, by a decrease in velocity of the action potential propagation along the non-myelinated nerve endings, which is mediated by activation of the α7 and α4β4 nicotinic cholinoreceptors.

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Tatarstan, Russia

    I. V. Kovyazina, A. N. Tsentsevitsky & E. E. Nikolsky

  2. Kazan Federal University, Kazan, Tatarstan, Russia

    I. V. Kovyazina, A. N. Tsentsevitsky & E. E. Nikolsky

  3. Kazan State Medical University, Kazan, Tatarstan, Russia

    E. E. Nikolsky

Authors
  1. I. V. Kovyazina
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  2. A. N. Tsentsevitsky
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  3. E. E. Nikolsky
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Correspondence to I. V. Kovyazina.

Additional information

Original Russian Text © I.V. Kovyazina, A.N. Tsentsevitsky, E.E. Nikolsky, 2016, published in Doklady Akademii Nauk, 2016, Vol. 468, No. 5, pp. 586–588.

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Kovyazina, I.V., Tsentsevitsky, A.N. & Nikolsky, E.E. Presynaptic nicotinic cholinoreceptors modulate velocity of the action potential propagation along the motor nerve endings at a high-frequency synaptic activity. Dokl Biol Sci 468, 115–117 (2016). https://doi.org/10.1134/S0012496616030133

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  • DOI: https://doi.org/10.1134/S0012496616030133

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