Abstract
The evoked responses of identified pyramidal tract neurons of the pericruciate region of the cortex arising on stimulation of the posterior, tuberal, and anterior sections of the lateral hypothalamus were investigated in acute experiments on cats anesthetized with chloralose. The pyramidal tract neurons recorded were situated at a depth of 0.75–2.5 mm and on stimulation of the hypothalamus discharged with a latent period of 1.6–52.5 msec. They discharged most efficiently in the case of stimulation of the caudal half of the lateral hypothalamus. The pyramidal tract neurons activated by the hypothalamus were also tested by electrocutaneous stimulation of the four limbs. Of the neurons 75% responded to stimulation of several limbs, i.e., they had a broad bilateral receptive field, while 15% reacted to stimulation of one contralateral limb (either the anterior limb or the posterior limb), i.e., they had a small contralateral receptive field. Comparison of the latent periods of the anti- and orthodromic responses of the pyramidal tract neurons did not reveal any relationship between the magnitude of the latent period of the orthodromic response (on hypothalamic or electrocutaneous stimulation) and the type of pyramidal tract neuron (according to the axonal transmission velocity). No relationship between the latent period of hypothalamic stimulation and the magnitude of the latent period of the response to a peripheral stimulus was detected either.
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É. B. Arushanyan and Yu. A. Belozertsev, “The influence of various sections of the hypothalamus on the activity of the neurons of the sensomotor zone of the cortex of the cat,” Neirofiziologiya,4, No. 2, 115–124 (1972).
É. G. Astvatsatryan, “Electrophysiological characterization of the presentation of the posterior hypothalamus in the neocortex,” Biol. Zh. Arm.,26, No. 4, 74–79 (1973).
E. G. Astvatsatryan and A. G. Mkrtchyan, “Evoked responses of the neurons of the sensomotor cortex to stimulation of the lateral hypothalamus,” Proceedings of the IV All-Union Conference on the Physiology of the Vegetative Nervous System [in Russian], Erevan (1976), p. 24.
O. G. Baklavadzhyan and É. G. Astvatsatryan, “Analysis of the electrical responses of the neocortex evoked by stimulation of various structures of the hypothalamus,” Fiziol. Zh. SSSR,62, No. 2, 160–168 (1976).
O. K. Baklavadzhyan, É. G. Astvatsatryan, A. G. Darbinyan, and V. S. Eganova, “Electrophysiological characterization of the hypothalamo-cortical potentials in cats,” Biol. Zh. Arm.,26, No. 9, 19–26 (1973).
T. A. Leontovich, “Principles of the qualitative and quantitative organization of the neurons of the subcortical and most primitive cortical formations of the forebrain of predators,” Author's Abstract of Dissertation (1973).
M. V. Morotina, “Investigation of the hypothalamocortical connections in rabbits,” Zh. Évol. Biokhim. Fiziol.,4, No. 2, 187–194 (1968).
T. N. Sollertinskaya, “The structural and functional interrelationships of phylogenetically different sections of the hypothalamus and the neocortex in rabbits,” Fiziol. Zh. SSSR,54, No. 4, 426–435 (1968).
V. M. Storozhuk, The Functional Organization of the Neurons of the Somatic Cortex [in Russian], Naukova Dumka, Kiev (1974).
T. Arikuni, “Inhibitory potentials produced in cortical cells by stimulation of the lateral hypothalamus in rabbits,” Brain Res.,111, No. 1, 41–52 (1976).
P. Buser and M. Imbert, “Sensory projections to the motor cortex in cats: a microelectrode study,” in: Sensory Communication, New York (1961), pp. 607–626.
J. Kievit and H. G. Kuypers, “Basal forebrain and hypothalamic connection to frontal and parietal cortex in the rhesus monkey,” Science,187, No. 4177, 660–662 (1975).
J. P. Murphy and E. Gellhorn, “The influence of hypothalamic stimulation on cortically induced movements and on action potentials of the cortex,” J. Neurophysiol.,8, No. 6, 341–364 (1945).
V. M. Pickel, M. Segal, and F. E. Bloom, “A radioautographic study of the efferent pathways of the nucleus locus coeruleus,” J. Comp. Neurol.,155, No. 1, 15–42 (1974).
T. Reunozo-Suarez, Topographischer Hirnatlas der Katze, Darmstadt (1961).
A. L. Towe, H. D. Patton, and T. T. Kennedy, “Properties of the pyramidal system in the cat,” Exp. Neurol.,8, No. 3, 220–238 (1963).
A. L. Towe, H. D. Patton, and T. T. Kennedy, “Response properties of neurons in the pericruciate cortex of the cat following stimulation of the appendages,” Exp. Neurol.,10, No. 4, 325–344 (1964).
A. L. Towe, D. Whitchorn, and J. K. Nyquist, “Differential activity among widefield neurons of the cat postcruciate cerebral cortex,” Exp. Neurol.20, No. 4, 497–521 (1968).
M. Tohyama, T. Maeda, and N. Shimizu, “Detailed noradrenaline pathways of locus coeruleus neurons to the cerebral cortex with use of 6-hydroxydopa,” Brain Res.,79, No. 1, 139–144 (1974).
U. Understedt, “Stereotaxic mapping of the monoamine pathways in the rat brain,” Acta Physiol. Scand.,82, Suppl. 367, 1–48 (1971).
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Translated from Fiziologicheskii Zhurnal SSSR, imeni I. M. Sechenova, Vol. 65, No. 5, pp. 661–667, May, 1979.
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Astvatsatryan, É.G., Mkrtchyan, A.G. & Baklavadzhyan, O.G. Evoked responses of pyramidal tract neurons to stimulation of the lateral hypothalamus. Neurosci Behav Physiol 11, 454–459 (1981). https://doi.org/10.1007/BF01182797
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DOI: https://doi.org/10.1007/BF01182797