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Interaction of calcium and somatostatin in the control of prolactin and somatotropin release from a primary culture of rat adenohypophyseal cells

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Conclusions

  1. 1.

    Lowering the extracellular Ca2+ concentration from 1.8 mM to 0.1 mM inhibited prolactin secretion but did not affect STH secretion in a culture of rat adenohypophyseal cells. Increasing extracellular Ca2+ to 5 mM had no effect on prolactin secretion but diminished somewhat STH release.

  2. 2.

    Somatostatin showed dose-related inhibition of STH and prolactin secretion in media with normal (1.8 mM) or low (0.1 mM) Ca2+ concentrations. Raising the Ca2+ concentration to 5 mM blocked the inhibitory effects of somatostatin on the release of these hormones.

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Authors and Affiliations

  1. Laboratory of Biological Hormone Standardization, Institute of Experimental Endocrinology and Hormone Chemistry, Academy of Medical Sciences of the USSR, Moscow

    V. I. Gudoshnikov, I. S. Komolov & V. P. Fedotov

Authors
  1. V. I. Gudoshnikov
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  2. I. S. Komolov
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  3. V. P. Fedotov
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Additional information

Translated from Problemy Éndokrinologii, Vol. 26, No. 6, pp. 50–53, November–December, 1980.

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Gudoshnikov, V.I., Komolov, I.S. & Fedotov, V.P. Interaction of calcium and somatostatin in the control of prolactin and somatotropin release from a primary culture of rat adenohypophyseal cells. Neurosci Behav Physiol 11, 440–442 (1981). https://doi.org/10.1007/BF01182793

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  • DOI: https://doi.org/10.1007/BF01182793

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