Summary
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1.
It was shown that the previously discovered reaction of formation of aminoalkylphosphonic acids by the action of ammonia on a mixture of dialkyl phosphite and an aldehyde or ketone can be extended to heterocylic ketones.
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2.
Esters of aminophosphonic acids of the piperidine and tetrahydropyran series and some of their derivatives were prepared.
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Literature cited
M. I.Kabachnik and T. Ya. Medved, Bull. Acad. Scl. USSR, Div. Chem, Sci. 1953, 868; 1954, 314.
I. N. Nazarov and V. A. Rudenko, Bull. Acad. Sci. USSR, Div. Chem. Sci. 1948, 610; I. N. Nazarov, V. Ya. Raigordskaya and V. A. Rudenko, Bull. Acad. Sci. USSR, Div. Chem. Sci. 1949, 504.
N. A. Preobrazhensky and E. I. Genkin, Chemistry of Organic Medicinal Substances (State Chem. Press, 1953), p. 249.
V. S. Abramov, J. Gen. Chem. 1952. 647.
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Medved, T.Y., Kabachnik, M.I. Synthesis of aminoalkylphosphonic acids the reaction of some heterocylic ketones with dialkylphosphites and ammonia. Russ Chem Bull 6, 1375–1380 (1957). https://doi.org/10.1007/BF01171895
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DOI: https://doi.org/10.1007/BF01171895