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Synthesis and three-dimensional structure of 3,5-dichloro-3,4,5,6-tetrahydropyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of N-chlorosuccinimide with 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine (phoridone) has been studied. Depending on the amount of chlorinating agent, 3,4,5,6-tetrahydropyridines with different degrees of chlorination were obtained. The three-dimensional structure of 3,5-dimethoxycarbonyl-4-(2-difluoromethoxyphenyl)-2-methyl-6-chloromethylene-3, 5-dichloro-3,4,5,6-tetrahydropyridine has been studied.

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References

  1. I. P. Skrastinysh, E. E. Liepin'sh, V. V. Kastron, and G. Ya. Dubur, Khim. Geterotsikl. Soedin., No. 4, 491 (1994).

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Authors
  1. V. V. Kastron
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  2. A. F. Mishnev
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  3. I. A. Skrastin'sh
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  4. G. Ya. Duburs
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Additional information

Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1118–1123, August, 1995. Original article submitted July 28, 1995.

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Kastron, V.V., Mishnev, A.F., Skrastin'sh, I.A. et al. Synthesis and three-dimensional structure of 3,5-dichloro-3,4,5,6-tetrahydropyridines. Chem Heterocycl Compd 31, 974–979 (1995). https://doi.org/10.1007/BF01170325

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  • DOI: https://doi.org/10.1007/BF01170325

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