Abstract
The bromination of 3-alkyl- and 3-ethoxycarbonyl-2-oxo-4-hydroxyquinolones by molecular bromine gave 3-bromo-3-R-2,4-dioxoquinolones. Under analogues conditions, 1-R-2,4-dioxo-3H-quinolone-3-carboxylic acids form 1-R-3-bromo-2-oxo-4-hydroxyquinolones. The results of the study of the antimicrobial activity of the compounds synthesized are presented.
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Additional information
For Communication 25, cf. [1].
Ukrainian Pharmaceutical Academy, Khar'kov, 310002. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 204–207, February, 1995. Original article submitted November 8, 1994.
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Ukrainets, I.V., Taran, S.G., Evtifeva, O.A. et al. 4-Hydroxy-2-quinolones. 26. Bromination of 3-substituted 2-oxo-4-hydroxyquinolones. Chem Heterocycl Compd 31, 176–179 (1995). https://doi.org/10.1007/BF01169675
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DOI: https://doi.org/10.1007/BF01169675