Abstract
The reaction of the esters of N-alkyl-N-phenylhydrazinocarbonylpropionic acids with phosphorus oxychloride in dioxane or with phosgene in benzene leads to the formation of the esters of 1-alkyl-2-aminoindolyl-3-acetic acids and of the corresponding N-alkyl-N-phenylaminosuccinimides.
Similar content being viewed by others
References
A. N. Kost, V. G. Zabrodnaya, Yu. N. Portnov, and V. G, Voronin, Khim. Geterotsikl. Soed., No. 4, 484 (1980).
V. G. Zabrodnaya, Candidate Dissertation [in Russian], MGU (1981).
V. P. Zhestkov and Yu. I. Portnov, “Chemistry, biochemistry, and pharmacology of indole derivatives,” 2nd AllUnion Conf., Abstracts of Papers [in Russian], Tbilisi (1991), p. 125.
G. Winters and Di Mola, US Patent 4, 113,731, Chem. Abstr.,90, 72161 (1979).
Yu. I. Portnov, V. P. Zhestkov, A. V. Blokhina, and V. G. Voronin, “Nitrogen-containing heterocycles,” 4th All-Union Conf., Abstracts of Papers [in Russian], Novosibirsk (1987), p. 210.
Additional information
All-Russian Center for the Safety of Biologically Active Substances (ARC BAS), Kupavna, Moscow Oblast 142450. Translated from Khimiya Geterots iklicheskikh Soedinenii, No. 11, pp. 1502–1506, November, 1995. Original article submitted September 2, 1995.
Rights and permissions
About this article
Cite this article
Zhestkov, V.P., Zabrodnaya, V.G. & Chernyshev, A.I. Synthesis of the esters of 1-alkyl-2-aminoindolyl-3-acetic acids by the kost reaction. Chem Heterocycl Compd 31, 1302–1306 (1995). https://doi.org/10.1007/BF01168624
Issue Date:
DOI: https://doi.org/10.1007/BF01168624