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Synthesis of Dicarboxylic Acid Amides and Diamides on the Basis of [4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methanamine

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Abstract

The condensation of various nonaromatic amines with ethyl N-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}oxamate prepared from [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methanamine and diethyl oxalate afforded the corresponding N,N'-disubstituted oxamides. N-Aryloxamides were synthesized by the reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methanamine with ethyl N-aryloxamates. The condensation of N-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}succinamic acid with primary amines gave N,N'-disubstituted siccinamides.

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Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    A. A. Aghekyan, G. G. Mkryan, R. E. Muradyan & A. E. Tumajyan

Authors
  1. A. A. Aghekyan
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  2. G. G. Mkryan
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  3. R. E. Muradyan
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  4. A. E. Tumajyan
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Correspondence to A. A. Aghekyan.

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Original Russian Text © A.A. Aghekyan, G.G. Mkryan, R.E. Muradyan, A.E. Tumajyan, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 6, pp. 884–889.

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Aghekyan, A.A., Mkryan, G.G., Muradyan, R.E. et al. Synthesis of Dicarboxylic Acid Amides and Diamides on the Basis of [4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methanamine. Russ J Org Chem 54, 886–891 (2018). https://doi.org/10.1134/S1070428018060106

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  • DOI: https://doi.org/10.1134/S1070428018060106

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