Abstract
3-Phosphotylated isoxazoles and isoxazolines react with nucleophiles either with cleavage of the P-C bond and subsequent ring opening or with retention of the heterocyclic ring depending on the structure of the ring substituents, nature of the nucleophile, and reaction conditions. This permits the selective chemical modification of the starting compounds.
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Additional information
Kazan State Technological University, Kazan 420015. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432. A. I. Gertsen Russian State Pedogogical University, St. Petersburg 191186. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 821–828, June, 1994. Original article submitted April 28, 1994.
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Pavlov, V.A., Kurdyukov, A.I., Gorin, B.I. et al. Phosphorylnitrile oxides. 5. Reactions of 3-(dialkoxyphosphoryl)isoxazoles and -isoxazolines with nucleophilic reagents. Chem Heterocycl Compd 30, 718–723 (1994). https://doi.org/10.1007/BF01166315
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DOI: https://doi.org/10.1007/BF01166315