Skip to main content
SpringerLink
Log in

Equilibrium potentials of the postsynaptic membrane of frog tonic fibers during changes in the extracellular ionic medium

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

The relation of membrane potential (MP) and amplitude of response to ionophoretic application of acetylcholine (ACh) to synaptic zones of isolated tonic (slow) fibers from the iliofibularis muscle of the frogRana temporaria was studied. The MP was shifted by intracellular polarization of the fiber. This relation is nonlinear in the region of hyperpolarization, mainly because of nonlinearity of the input resistance of the fibers. In experiments on 15 fibers the reversal potential of the response to ACh application, which coincided with the equilibrium potential (Ep) of the postsynaptic membrane, was −8 ±0.7 mv. With a decrease in [K+]n by 80%, Ep was shifted toward the potassium equilibrium potential and its value was −21±1.3 mv. The values of Ep for the postsynaptic membrane of fast and slow fibers evidently differ slightly, but the character of the dependence of Ep on [K+]n is approximately the same for both fast and slow fibers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. KUFLER, S.W. and E.M. VAUGHAN-WILLIAMS. J. Physiol. (London) 129:289, 1953.

    Google Scholar 

  2. BURKE, W. and B.L. GINSBORG. J. Physiol. (London) 132:586, 1956.

    Google Scholar 

  3. OOMURA, Y. and T. TOMITA. In: Electrical Activity of Single Cells, New York, 1960, p. 181.

  4. ADRIAN, R.H. and D. PEACHEY. J. Physiol. (London) 181:324, 1965.

    Google Scholar 

  5. TAKEUCHI, A. and N. TAKEUCHI. J. Physiol. (London) 154:52, 1960.

    Google Scholar 

  6. DUNIN-BARKOVSKII, V.L., S.A. KOVALEV, L. G. MAGAZANIK, T. V. POTAPOVA and L.M. CHAILAKHYAN. Biofizika. 14:485, 1969.

    Google Scholar 

  7. BURKE, W. and B.L. GINSBORG. J. Physiol. (London) 132:599, 1956.

    Google Scholar 

  8. GINSBORG, B.L. Pharmacol. Rev. 19:289, 1967.

    Google Scholar 

  9. NASLEDOV, G.A., J. ZACHAR and D. ZACHAROVA. Physiol. Bohemoslov. 15:293, 1966.

    Google Scholar 

  10. MAGAZANIK, L.G. and T.V. POTAPOVA. Biofizika. 14:658, 1969.

    Google Scholar 

  11. TAKEUCHI, N., J. Physiol. (London) 167:128, 1963.

    Google Scholar 

  12. HESS, A. Amer. J. Anat. 107:129, 1960.

    Google Scholar 

  13. NASLEDOV, G.A. and V.V. FEDOROV. Arkh. Anat. Gistol. Embriol. 49:72, 1965.

    Google Scholar 

  14. NASLEDOV, G.A. Zh. Evol. Biokhim. Fiziol. 5:398, 1969.

    Google Scholar 

  15. POTAPOVA, T.V. Biofizika. 14:757, 1969.

    Google Scholar 

  16. MAGAZANIK, L.G. and S. VYSKOCIL. Experientia. 25:618, 1969.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad

    L. G. Magazanik & G. A. Nasledov

Authors
  1. L. G. Magazanik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. Nasledov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Magazanik, L.G., Nasledov, G.A. Equilibrium potentials of the postsynaptic membrane of frog tonic fibers during changes in the extracellular ionic medium. Neurosci Behav Physiol 5, 79–85 (1972). https://doi.org/10.1007/BF01163382

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01163382

Keywords

Search

Navigation