Abstract
Interaction between two antagonistic mediators, acetylcholine and serotonin, was investigated by a kinetic method on the isolated ventricle ofMytilus grayanus andNeptunea sp. When both substances act simultaneously on the myocardium, they behave as antagonists of competitive and mixed types. Similar results were obtained on the isolated frog ventricle during simultaneous action of acetylcholine and adrenalin on the myocardium. Nonspecific factors inducing reversible denaturation of proteins (brief exposure to a high temperature or to 15% urea) led to temporary blocking of sensitivity to both mediators. After their action the sensitivity of the frog heart muscle to acetylcholine and adrenalin is gradually restored, and the recovery curves for the two mediators coincide. The identity of the receptor proteins for the antagonistic mediators is discussed.
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References
KOSHTOYANTS, Kh. S. Enzyme Chemistry of Excitation and Inhibition Processes and Evolution of Functions of the Nervous System. USSR Acad. Sci. Press, Moscow, 1963.
WOOLEY, G.W. and B.W. GOOMI. Arch. Int. Pharmacodyn. 159:8, 1966.
TURPAEV, T.M. The Mediator Function of Acetylcholine and the Nature of the Cholinergic Receptor. USSR Acad. Sci. Press, Moscow, 1962.
MANUKHIN, B.N. The Physiology of Adrenergic Receptors. Nauka, Moscow, 1968.
PUTINTSEVA, T.G. and N.A. RESHETNIKOVA. Fiziol. Zh. SSSR im. I.M. Sechenova. 56:1020, 1970.
TURPAEV, T.M. and B.N. MANUKHIN. Proceedings of the 5th All-Union Conference on Neurochemistry. Tbilisi, 1970, p. 345.
TURPAEV, T.M. In: Current Problems in the Physiology and Pathology of the the Cardiovascular System. Meditsina, Moscow, 1967.
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Manukhin, B.N., Turpaev, T.M. Identity of the acetylcholine, adrenalin and serotonin receptors. Neurosci Behav Physiol 5, 70–78 (1972). https://doi.org/10.1007/BF01163381
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DOI: https://doi.org/10.1007/BF01163381