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Conditioning of single unit activity by intracortical electric stimulation of neuronal-isolated cortex

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Abstract

Changes in cortical unit activity during formation of temporary connections by direct electrical stimulation of two points in the isolated cortex were studied in acute experiments on cats under nembutal anesthesia. The cortex was isolated by Khananashvili's method (7). After repeated paired stimulation of the association and auditory areas of the cortex some neurons in the former begin to respond to stimulation of the latter alone, i.e., to stimulation which previously had caused no changes in background activity of the units tested. This temporary connection readily underwent extinction, was restored when stimulus pairing resumed, and was maintained for a certain time interval. It is suggested that these neurons play an important role in the organization of intrinsic cortical mechanisms for the fixation of trace responses and that they may represent a component of the cortical microsystem responsible for short term memory.

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Authors and Affiliations

  1. Pavlov Department of Physiology, Institute of Experimental Medicine, USSR Academy of Medical Sciences, Leningrad

    M. M. Khananashvili, E. G. Zakreshev & V. L. Silakov

Authors
  1. M. M. Khananashvili
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  2. E. G. Zakreshev
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  3. V. L. Silakov
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Khananashvili, M.M., Zakreshev, E.G. & Silakov, V.L. Conditioning of single unit activity by intracortical electric stimulation of neuronal-isolated cortex. Neurosci Behav Physiol 5, 24–30 (1972). https://doi.org/10.1007/BF01163375

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