Skip to main content
SpringerLink
Log in

Synthesis and crystal and molecular structure of newN-substituted γ-hydroxybutyramides

  • Published:
Journal of Crystallographic and Spectroscopic Research Aims and scope Submit manuscript

Abstract

TheN-(2-phenylethyl)amide ofα-(1′, 1′-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (II) and theN-(p-methoxybenzyl)amide ofα-(1′, 1′-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (III) have been synthesized and the crystal structure ofIII has been solved. CompoundIII, C16H23O5N, crystallizes in the monoclinic space groupP21/c witha=12.572(2),b=11.149(2),c=12.317(2) Å andβ=106.53(1)°. The structure was solved by direct methods, and refined by full-matrix least squares to giveR=0.040 (R w =0.047) for 2004 intensities. The dioxolane ring has a deformed half-chair conformation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Duax, W. L., and Norton, D. A. (1975)Atlas of Steroid Structure (Plenum Press, New York).

    Google Scholar 

  • Ducruix, A., and Pascard-Billy, C. (1977)Acta Cryst. B 33, 1384.

    Google Scholar 

  • Dunitz, J. D. (1976)X-Ray Analysis and the Structure of Organic Molecules. (Cornell University, Press, Ithaca/London), p. 328.

    Google Scholar 

  • Krogsgaard-Larsen, P., Faloch, E., and Hjeds, H. (1985)Prog. Med. Chem. G. Ellis and G. West, eds.22, 67.

  • Malawska, B., Gorczyca, M., and Malec, D. (1988) Xth International Symposium on Medicinal Chemistry, Budapest 1988, p. 244.

  • Roberts, E., Chase, T. N., and Tower, D. B. (1976)GABA in Nervous System Function. (Raven Press, New York).

    Google Scholar 

  • Ruzić-Toros, Z., and Leban, I. (1978)Acta Cryst. B 34, 1226.

    Google Scholar 

  • Sheldrick, G. M. (1976)Shelx 76, A program for crystal structure determination (University of Cambridge, England).

    Google Scholar 

  • Sheldrick, G. M., Kruger, C., and Goddard, R. (1985)Shelx-86Crystallographic Computing 3. (Oxford University Press), p. 175.

  • Snead, O. C., and Nichols, A. C. (1987)Neuropharmacology 26, 1519.

    Google Scholar 

  • Winkler, F. K., and Dunitz, J. D. (1971)J. Mol. Biol. 59, 169.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Medical Academy, Skaleczna 10, 31-065, Kraków, Poland

    B. Malawska & M. Gorczyca

  2. Institute of General Chemistry, Technical University, Żwirki 36, 90-924, Lódź, Poland

    W. Wieczorek

Authors
  1. B. Malawska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Gorczyca
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Wieczorek
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malawska, B., Gorczyca, M. & Wieczorek, W. Synthesis and crystal and molecular structure of newN-substituted γ-hydroxybutyramides. Journal of Crystallographic and Spectroscopic Research 20, 139–144 (1990). https://doi.org/10.1007/BF01160965

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01160965

Keywords

Search

Navigation