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Degree of ionization and active form of anesthetics

  • The Research for New Drugs
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Pharmaceutical Chemistry Journal Aims and scope

Conclusions

  1. 1.

    The anesthetics studied exist primarily in the cationic form at pH 3.5, 5.0, 6.0, 7.0, and 7.35.

  2. 2.

    The concentration of the ionized form of an anesthetic in the nerve at various external pH values is more constant in comparison with the concentration of the nonionized base.

  3. 3.

    The nonionized base is important for the penetration of the anesthetic to the reaction site; the cationic form is responsible for the interaction of the anesthetic with the receptor.

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Literature cited

  1. N. T. Pryanishnikova, in: Materials of the Eighth All-Union Conference of Pharmacologists [in Russian], Tbilisi (1960), p. 125.

  2. N. T. Pryanishnikova, in: Materials of the First National Bulgarian Conference on Experimental Medicine [in Russian], Sofia (1961), p. 28 (Citation 5).

  3. N. T. Pryanishnikova, in: Pain and Its Control [in Russian], Sverdlovsk (1966), p. 181.

  4. N. T. Pryanishnikova and V. A. Pchelin, Dokl. AMN SSSR,126, No. 6, 1358 (1959).

    Google Scholar 

  5. N. T. Pryanishnikova and N. A. Sharov, Novocaine, Pharmacology and Clinical Application [in Russian], Leningrad (1967), p. 101.

  6. V. M. Samvelyan, Izv. AN Armyansk. SSR, Seriya Biol. Nauk,16, No. 9, 17 (1963).

    Google Scholar 

  7. A. Albert, Pharmacol. Rev.,4, 136 (1952).

    Google Scholar 

  8. E. J. Ariens and A. M. Simonis, Arch. Int. Pharmacodyn,141, 309 (1963).

    Google Scholar 

  9. T. C. Daniels, W. D. Kumler, Ch. O. Wilson, and O. Giswold, Textbook of Organic Medicinal and Pharmaceutical Chemistry, Philadelphia (1956), p. 3.

  10. J. H. Gardner and J. J. Semo, J. Pharmacol. Exp. Ther.,54, 267 (1935).

    Google Scholar 

  11. O. Gross, Arch. Exp. Path. Pharmakol.,63, 80 (1910).

    Google Scholar 

  12. J. M. Ritchie and P. Greengard, J. Pharmacol. Exp. Ther.,133, 241 (1961).

    Google Scholar 

  13. Idem, Ann. Rev. Pharmacol.,6, 405 (1966).

    Google Scholar 

  14. J. M. Ritchie, B. R. Ritchie, and P. Greengard, J. Pharmacol. Exp. Ther.,150, 152, 160 (1965).

    Google Scholar 

  15. J. C. Skou, Acta. Pharmacol. (Kbh.),10, 281 (1954).

    Google Scholar 

  16. Idem, J. Pharm., London,13, 204 (1961).

    Google Scholar 

  17. J. C. Skou and K. Zerahn, Biochim. Biophys. Acta.,35, 324 (1959).

    Google Scholar 

  18. J. W. Trevan and E. Book, Brit. J. Exp. Path.,8, 307 (1927).

    Google Scholar 

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Authors and Affiliations

  1. Scientific-Research Institute of Pharmacology and Chemotherapy, Academy of Medical Sciences of the USSR, Moscow

    N. T. Pryanishnikova

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  1. N. T. Pryanishnikova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 1, pp. 35–39, January, 1970.

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Pryanishnikova, N.T. Degree of ionization and active form of anesthetics. Pharm Chem J 4, 33–37 (1970). https://doi.org/10.1007/BF01159410

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  • DOI: https://doi.org/10.1007/BF01159410

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