Conclusions
Sixteen alkylamino esters and amides of α,α-diphenyl-α-ethoxyacetic acid and α,α-diphenylpropionic acid have been synthesized and investigated pharmacologically. All the compounds prepared possess spasmolytic and cholinolytic properties. Derivatives of α,α-diphenyl-α-ethoxyacetic acid are also characterized by the presence of analgesic and anti-cough action. Loading the alcoholic or acid part of the molecule, or replacement of the ester bond by an amide bond, leads to weakening of activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 1, pp. 9–14, January, 1970.
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Liberman, S.S., Mastafanova, L.I. & Kopylova, N.A. Synthesis and pharmacological study of some alkylamini esters and amides of α,α-diarylaliphatic acids. Pharm Chem J 4, 7–11 (1970). https://doi.org/10.1007/BF01159404
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DOI: https://doi.org/10.1007/BF01159404