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Effect of catecholaminergic drugs on epileptogenic properties of the caudate nucleus

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Abstract

Drugs stimulating catecholaminergic transmission (dopa, apomorphine, amphetamine, and their combination with disulfiram) weakened the epileptogenic properties of the caudate nucleus in freely moving rats. Under the influence of these drugs the cortical electroencephalographic response to single stimulation of the nucleus was shortened in animals receiving subconvulsant doses of leptazol and the intensity of the spike-wave rhythm bound with repeated caudate stimuli was reduced. Conversely, inhibitors of catecholaminergic transmission (chlorpromazine, haloperidol, α-methyltyrosine, and disulfiram) potentiated the epileptogenic effects of the caudate nucleus.

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Literature cited

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Authors and Affiliations

  1. Department of Pharmacology, Medical Institute, Chita

    R. M. Avakyan & É. B. Arushanyan

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  1. R. M. Avakyan
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  2. É. B. Arushanyan
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 66–69, August, 1975.

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Avakyan, R.M., Arushanyan, É.B. Effect of catecholaminergic drugs on epileptogenic properties of the caudate nucleus. Neurosci Behav Physiol 7, 13–16 (1976). https://doi.org/10.1007/BF01148741

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  • DOI: https://doi.org/10.1007/BF01148741

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