Abstract
Experiments on rats have shown that administration of a synthetic analog of leucine enkephalin at a dose of 100 mg/kg did not change the content of the immunoreactive parathyroid hormone in the blood plasma, but eliminated the parathyroidin-stimulating effect on the cAMP concentration in the renal tissue and AP activity in the blood. We conclude that enkephalins do not influence the secretion and metabolism of the parathyroid hormone, but block its peripheral effects and stimulate thyroid C-cell function.
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V. G. Smagin, V. A. Vinogradov, and S. A. Bulgakov, Opiate Receptor Ligands [in Russian], Moscow (1983).
Yu. B. Lishmanov, G. K. Zoloev, and V. D. Slepushkin, Byull. Sib. Otd. Akad. Med. Nauk SSSR, No. 5, 65–67 (1982).
V. D. Romanenko, Physiology of Calcium Metabolism [in Russian], Kiev (1975).
I. I. Kochereina, New Data on Thyrocalcitonin and Its Applications [in Russian], Moscow (1975).
I. A. Drzhevetskaya and Yu. M. Drzhevetskii, Hormonal Regulation of Calcium Metabolism and Secretory Processes [in Russian], Moscow (1983).
G. K. Zoloev, “Role of parathyroid hormone, calcitonin, and glucocorticoids in impairments of the calcium balance and its correction at post-aggressive states (myocardial infarct, trauma),” Author's Abstract of Candidate's Dissertation, Tomsk (1983).
D. Pickar, M. R. Cohen, M. Dubous, et al., Psychopharmacol. Bull.,18, 208–211 (1982).
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Translated from Problemy Éndokrinologii, Vol, 31, No. 1, pp. 42–44, January–February, 1985.
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Zoloev, G.K., Slepushkin, V.D., Akhmetshina, A.G. et al. Effect of enkephalins on the function of calcium-regulating endocrine glands. Neurosci Behav Physiol 16, 295–297 (1986). https://doi.org/10.1007/BF01148171
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DOI: https://doi.org/10.1007/BF01148171