Summary
The studied derivatives of malonaldehyde had measurable crosslinking properties, even though much less pronounced than malonaldehyde. The optimum conditions for the reaction of these compounds were in the same pH range, around pH 4. It was shown that the substitution of malonaldehyde entailed a considerable decrease of its initially high reactivity. The polar effects of substituents influenced the electron acceptor function of malonaldehyde in accordance with established mechanism of aldolization.
Zusammenfassung
Die verwendeten Derivate des Malonaldehydes vernetzen das Kollagen, wenn auch in viel kleinerem Ausmaß. Das Optimum der Reaktion liegt im gleichen Bereich bei pH um 4. Es hat rich gezeigt, daß durch die Substitution des Malonaldehydes dessen große Aktivität gestört wird. Polare Effekte der Malonaldehyd-Substituenten beeinflussen die Elektronacceptor-Fähigkeit des Malonaldehydes im Einklang mit dem allgemein gültigen Mechanismus der Aldolisation.
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Švadlenka, I., Davídková, E. & Rosmus, J. Interaction of malonaldehyde with collagen. Z Lebensm Unters Forch 153, 312–315 (1973). https://doi.org/10.1007/BF01140364
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DOI: https://doi.org/10.1007/BF01140364