Summary
A bacterium able to grow at 46°C was isolated from soil and identified asBacillus licheniformis. L-Lysine producing mutants were derived from the bacterium by the introduction of resistance to S-(2-amino)-ethylcysteine (thialysine) and auxotrophy.One of the mutants, HBR-2 (Thialysiner, Leu−, Homoserine−), produced L-lysine at a concentration of 30 mg/ml in a molasses medium containing 10% reducing sugar.
Similar content being viewed by others
References
Hino, T., Ito K., Hayashi, K., and Abe, N. (1960). Nippon-Nogei Kagakukaishi, 34, 22 - 27.
Kinoshita, S., Nakayama, K., and Kitada, S. (1958). J. gen. Appl. Microbiol., 4, 128 - 129.
Nakayama, K., and Kinoshita, S. (1961). Nippon Nogei Kagakukaishi, 35, 119 - 121.
Nakayama, K., Kitada, S., and Kinoshita, S. (1961). J. gen. Appl. Microbiol., 7, 145 - 154.
Stahly, D. P., and Bernlohr, R. W. (1967). Biochim. Biophys. Acta, 146, 467 - 476.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hagino, H., Kobayashi, S. & Araki, K. L-Lysine production by mutants of Bacillus licheniformis. Biotechnol Lett 3, 425–430 (1981). https://doi.org/10.1007/BF01134102
Issue Date:
DOI: https://doi.org/10.1007/BF01134102