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Initiation of DNA synthesis in quiescent Swiss 3T3 and 3T6 cells by lanthanum

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Bioscience Reports

Abstract

La3+ stimulated quiescent Swiss 3T3 and 3T6 ceils to enter the DNA-synthesizing S phase of the cell cycle. La3+ and insulin interacted synergistically to increase DNA synthesis. A brief exposure of the cells to soluble LaCl3 optimally stimulated entry into S. La3+ was similar to Al3+ in its mitogenic properties (J. Cell. Physiol.118 , 298, 1984), but La3+ was 10 times more potent than Al3+.

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Authors and Affiliations

  1. Department of Pharmacology, University of Alabama in Birmingham, Volker Hall, P.O. Box 191, 35294, Birmingham, AL, USA

    Jeffrey Bingham Smith & Lucinda Smith

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  1. Jeffrey Bingham Smith
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  2. Lucinda Smith
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Smith, J.B., Smith, L. Initiation of DNA synthesis in quiescent Swiss 3T3 and 3T6 cells by lanthanum. Biosci Rep 4, 777–782 (1984). https://doi.org/10.1007/BF01128819

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  • DOI: https://doi.org/10.1007/BF01128819

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