Skip to main content
SpringerLink
Log in

The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat

  • Published:
Archives of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

Male, Sprague-Dawley rats were treated with 0, 1, 10, 50, 100 ppm chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. A significant decrease in body weight gain was observed in 100 ppm of Cd-treated rats. Cholinesterase (ChE) activity was significantly decreased in serum of Ca-D rats. Chlordecone did not alter serum ChE activity in both Ca-S and Ca-D rats. However, Cd decreases serum triglycerides, low density lipoproteins (LDL) and cholesterol in both Ca-S and Ca-D rats. Rats fed with Ca-S or Ca-D diet exhibited differential sensitivity to Cd-toxicity. Decreased levels of serum triglycerides, LDL and cholesterol suggest that Cd might interfere in lipid metabolism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Atwal (1973) Fatty changes and hepatic cell excretion in avian liver. An electron microscopic study of Kepone® toxicity. J Comp Pathol 83:115–124

    Google Scholar 

  • Aungst BJ and Fung HL (1985) The effects of dietary calcium on lead absorption, distribution and elimination kinetics in rats. J Toxicol Environ Health 16:147–159

    Google Scholar 

  • Brown MS, Kovanen PT, Goldstein JL (1981) Regulation of plasma cholesterol by lipoprotein receptors. Science 212:628–635

    Google Scholar 

  • Desaiah D (1981) Interaction of chlordecone with biological membranes. J Toxicol Environ Health 8:719–730

    Google Scholar 

  • (1982) Biochemical mechanisms of chlordecone neurotoxicity. A Review. Neurotoxicology 3(2):103–110

    Google Scholar 

  • Egle JL, Fernandez SB, Guzelian PS, Borzelleca JF (1979) Distribution and excretion of chlordecone (Kepone®) in the rat. Drug Metab Dispos 6:91–95

    Google Scholar 

  • Eroschenko VP (1981) Estrogenic activity of the insecticide chlordecone in the reproductive tract of birds and mammals. J Toxicol Environ Health 8:707–718

    Google Scholar 

  • Goldberg IJ, Le NA, Paterniti JR, Ginsberg HN, Lindgren FT, Brown WV (1982) Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in Cynomolgus monkey. J Clin Invest 70:1184–1192

    Google Scholar 

  • Hoskins B, Ho IK (1982) Chlordecone-induced alterations in content and subcellular inhibition of calcium in mouse brain. J Toxicol Environ Health 9:535–544

    Google Scholar 

  • Kohli KK, Sharma SC, Bhatia SC, Venkitasubramanian TA (1975) J Sci Ind Res 34:462

    Google Scholar 

  • Kubena LF, Huff WK, Harvey RB (1989) Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks. Poultry Sci 68:622–626

    Google Scholar 

  • Kutty KM, Jacob JC, Hutton CJ, Davis PJ, Peterson SC (1975) Serum beta-lipoproteins: studies in a patient and in guinea-pigs after the ingestion of organophosporus compounds. Clin Biochem 8:379–383

    Google Scholar 

  • McFarland LZ, Lacy PB (1969) Physiologic and endocrinologic effects of the insecticide kepone in the Japanese quail. Toxicol Appl Pharmacol 15:441–450

    Google Scholar 

  • Mehendale HM (1981) Chlordecone-induced hepatic dysfunction. J Toxicol Environ Health 8:743–755

    Google Scholar 

  • Musliner TA, Herbert PN, Kingston MJ (1979) Lipoprotein substrates of lipoprotein lipase and hepatic triacylglycerol lipase from human postheparin plasma. Biochim Biophys Acta 575:277–288

    Google Scholar 

  • Mylroie AA, Moore L, Olyai B, Anderson M (1978) Increased susceptibility to lead toxicity in rats fed semi-purified diets. Environ Res 15:57–64

    Google Scholar 

  • Nageswara Rao T, Subrahmanyam D (1981) Effect of DDT on adipose tissue lipolysis in rat. Toxicology 20:229–235

    Google Scholar 

  • Ryhanen R, Herranen J, Korhonen K, Penttila I, Polvilampi M, Puhakainen E (1984) Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits. Int J Biochem 16(6):687–690

    Google Scholar 

  • Sanyal S, Agarwal N, Sheorain VS, Khuller GK, Chakravarti RN, Subrahmanyam D (1979) Pestic Biochem Physiol 12:31

    Google Scholar 

  • Sorrell M and Rosen JF (1977) Interactions of lead, calcium, vitamin D and nutrition in lead burdened children. Arch Environ Health 34:160–164

    Google Scholar 

  • Taylor JR, Selhorst JB, Houff SA, Martinez AJ (1978) Chlordecone intoxication in man. 1: Clinical observations. Neurology 28:626–633

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences, Grambling State University, 71245, Grambling, Louisiana, USA

    K. N. Chetty, J. Walker & K. Brown

  2. Food and Animal Protection Research Laboratory, United States Department of Agriculture, Agriculture Research Services, 77845, College Station, Texas, USA

    G. W. Ivie

Authors
  1. K. N. Chetty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. W. Ivie
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chetty, K.N., Walker, J., Brown, K. et al. The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat. Arch. Environ. Contam. Toxicol. 24, 365–367 (1993). https://doi.org/10.1007/BF01128735

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01128735

Keywords

Search

Navigation