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Effects of direct injection of mediators and substances influencing their metabolism into the amygdala, septum and hypothalamus in cats

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Summary

  1. 1.

    A method of chemical stimulation of the cat brain by microinjections through stereotaxically implanted needles is described.

  2. 2.

    Of all the compounds tested, only acetylcholine and serotonin affected behavior. The effects of microinjections of acetylcholine and serotonin were modified unequally by preliminary intramuscular injection of the central cholinolytic benactyzine and the pharmacologically closely related antidepressant imipramine.

  3. 3.

    Microinjections of compounds affecting serotonin metabolism (its precursor, 5-hydroxytryptophan, its antagonist BOL 148, and tetrabenazine, liberating serotonin from the tissues) and noradrenalin metabolism (inhibitors of synthesis, α-methyltyrosine and α-methyl-m-tyrosine; amphetamine, a stimulant liberating noradrenalin) into the three investigated areas led to no significant changes in behavior.

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References

  1. ALLIKMETS, L. Kh. Zh. Vyssh. Nerv. Deyatel'nosti im I.P. Pavlova. 16:1082, 1966. (Translation published in Neuroscience Translations No. 2:119–127, 1967–68).

    Google Scholar 

  2. ALLIKMETS, L. Kh. and M. E. DITRIKH. Zh. Vyssh. Nerv. Deyatel'nosti im I. P. Pavlova. 15:86, 1965. (Translation published in Federation Proceedings, Part II, Translation Supplement 25:T1003–T1007, 1965).

    Google Scholar 

  3. ALLIKMETS, L. Kh. and I. P. LAPIN. Activ. Nerv. Super. 8:129, 1966.

    Google Scholar 

  4. VEDYAEV, F. P. and L. Kh. ALLIKMETS. Zh. Evolyuts. Fiziol. Biokhim. 2:480, 1966.

    Google Scholar 

  5. GELLHORN, E. and G. LOOFBOURROW. Emotions and Emotional Disorders (Russian translation). Mir Press, Moscow, 1966.

    Google Scholar 

  6. GORKIN, V. Z. In: Molecular Basis of Pathology. Moscow, 1966, p. 179.

  7. KASSIL', G. N. In: Current Problems in the Physiology and Pathology of the Nervous System. Moscow, 1965, p. 358.

  8. MIKHEL'SON, M. Ya. and E. L. SHCHELKUNOV. In: Effect of Psychotropic Drugs on Higher Nervous Activity. Leningrad, 1963, p. 43.

  9. SAARMA, Yu. and L. ALLOKMETS. 18th International Psychological Congress, Symposium 8. Moscow, 1966, p. 61.

    Google Scholar 

  10. SMIRNOV, V. M. Vop. Psikhol. 3:85, 1966.

    Google Scholar 

  11. ALLIKMETS, L. H. and I. P. LAPIN. Int. J. Neuropharmacol. 6:99, 1967.

    Google Scholar 

  12. FELDBERG, W. A Pharmacological Approach to the Brain from its Innter and Outer Surface. London, 1963.

  13. GLOWINSKI, J. and R. J. BALDESSARINI. Pharmacol. Rev. 18:1201, 1966.

    Google Scholar 

  14. HERNANDEZ-PEON, R., G. CHAVEZ-IBARRA, P. J. MORGANE and C. TIMOIARIA. Exp. Neurol. 9:93, 1963.

    Google Scholar 

  15. 5-Hydroxytryptamine and Related Indolealkylamines. Handbuch der Experimentella Pharmakologie, Berlin, 1966, p. 19.

  16. MILLER, N. E. Science. 148 (3663):328, 1965.

    Google Scholar 

  17. Second Symposium on Catecholamines. Pharmacol. Rev. 18(1):1966.

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Author information

Authors and Affiliations

  1. Central Medical Research Laboratory, Tartu University, Tartu, USSR

    L. Kh. Allikmets, V. A. Vakhing & I. P. Lapin

  2. Tartu Republic Clinical Psychoneurological Hospital, Tartu, USSR

    L. Kh. Allikmets, V. A. Vakhing & I. P. Lapin

  3. Department of Psychopharmacology, Bekhterev Leningrad Psychoneurological Research Institute, Leningrad, USSR

    L. Kh. Allikmets, V. A. Vakhing & I. P. Lapin

Authors
  1. L. Kh. Allikmets
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  2. V. A. Vakhing
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  3. I. P. Lapin
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Allikmets, L.K., Vakhing, V.A. & Lapin, I.P. Effects of direct injection of mediators and substances influencing their metabolism into the amygdala, septum and hypothalamus in cats. Neurosci Behav Physiol 2, 985–990 (1968). https://doi.org/10.1007/BF01124751

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  • DOI: https://doi.org/10.1007/BF01124751

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